Table 3. The number of circulating blood cells in WT, DREAM KO, and BM chimeric mice.
| WBC (103/µl) | NE (103/µl) | LY (103/µl) | MO (103/µl) | RBC (106/µl) | PLT (106/µl) | MPV (fl) | |
|---|---|---|---|---|---|---|---|
| WT (CD45.1) | 5.2 ± 2.7 | 0.8 ± 0.2 | 4.0 ± 1.5 | 0.2 ± 0.0 | 7.4 ± 1.7 | 882 ± 164 | 5.9 ± 0.9 |
| DREAM KO | 3.6 ± 0.8 | 0.7 ± 0.2 | 2.9 ± 1.3 | 0.1 ± 0.0 | 7.5 ± 1.4 | 976 ± 193 | 5.9 ± 1.0 |
| BM chimeric mice | 5.4 ± 1.7 | 0.9 ± 0.2 | 4.2 ± 1.7 | 0.3 ± 0.1 | 8.8 ± 1.0 | 1,215 ± 219 | 6.3 ± 1.0 |
The blood was obtained from 8–10-wk-old male WT (B6.SJL-PtprcaPepcb/BoyJ, a C57BL/6 congenic strain [CD45.1]) and DREAM KO mice and from BM chimeric mice at 6 wk after transplantation of an equal number of WT and KO BM cells into WT (CD45.1) mice. Blood cells were counted using HEMAVET 950 (Drew Scientific). Data represent the mean ± SD (n = 6 mice per group). WBC, white blood cells; NE, neutrophils; LY, lymphocytes; MO, monocytes; PLT, platelets; MPV, mean platelet volume.