Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 17;9:802502. doi: 10.3389/fcell.2021.802502

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Qin, Lv, Zhang, Ruan, Xu, Chen, Ji, Lu and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Drp1 inhibitor Mdivi-1 showed similar effects with OSE in DOX-exposed H9C2 cells. (A) Mdivi-1 decreased the elevated Drp1 expression and suppressed the enhanced autophagic activity in DOX-treated H9C2 cells, similarly like OSE. (B) Mdivi-1 reduced PINK1 accumulation on mitochondria and prevent Parkin translocation from cytosol to mitochondria in DOX-induced H9C2 cells. (C) Consistent with the effects of OSE, Mdivi-1 suppressed apoptotic activity in DOX-induced H9C2 cells. (D) Representative TUNEL staining images showing that Mdivi-1 suppressed the enhanced apoptosis in DOX-induced H9C2 cells, similarly like OSE.