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. 2021 Dec 31;16(12):e0256885. doi: 10.1371/journal.pone.0256885

Fig 1. Animal study design and immunization schedule.

Fig 1

Infant rhesus macaques from four immunization schedules were included. HIV Env+adjuvant group was immunized with MVA-SIV gag/pol and HIV Envelope (Env) 1086c adjuvanted with 15 μg STS, intramuscular + 200 μg R848, intranasal. Co-administration group was immunized with MVA-SIV gag/pol, HIV Env 1086c adjuvanted with 15 μg STS, intramuscular + 200 μg R848, intranasal), and with MVA-HIV Env. Extended interval group was immunized with similar immunogens as Co-administration group with longer immunization intervals. 3M-052-SE group was immunized with HIV Env 1086c/TV1 bivalent adjuvanted with 15 μg/15 μg+3M-052-SE, intramuscular. Plus symbol (+) denoted necropsy, IM denoted intramuscular, IN denoted intranasal, and IU denoted infectious unit.