Fig 4. Frequency of somatic hypermutation and heavy chain complementarity-determining region 3 (HCDR3) length of vaccine-elicited Env-reactive functional heavy- and light-chains identified using rhesus Ig sequence database.

(A) Analysis of percent somatic hypermutation frequency and HCDR3 lengths for Env-reactive heavy and light chains pairs (39 mAb pairs) from infant antigen-specific B cells based on human immunoglobulin (Ig) sequence database. (B) Analysis of percent somatic hypermutation frequency and HCDR3 lengths for Env-reactive heavy- and light-chains functional pairs (26 mAb pairs) from vaccinated infant antigen-specific memory B cells using rhesus Ig-gene database. Horizontal lines indicated median values of individual groups. Corresponding functional heavy and light chains isolated from individual infants are denoted by symbols.