Table 1. Frequency of Env-specific memory B cells in sorted tissues and PBMCs of envelope-vaccinated infant monkeys.
| Percent (%) Ag+ Memory B Cells | ||||||
|---|---|---|---|---|---|---|
| Group | Animal ID | Spleen | Axillary LN | Oral LN¶ | Colon/Ileum | PBMC W10/12 |
| HIV Env+adjuvant | 45519 | ND | ND | ND | ND | 0.84 |
| 45521 | 0.27* | ND | 0.17* | ND | ND | |
| 45522 | 0.1* | ND | 0.07* | ND | 1.72 | |
| Co-administration | 45038 | ND | ND | ND | ND | 0.36 |
| 45047 | ND | ND | ND | ND | 0.16 | |
| 45069 | ND | ND | ND | ND | 0.15 | |
| 45083 | 0.06 | ND | 0.32* | ND | 0.14 | |
| 45091 | 0.06 | 0.97 | ND | ND | 0.23 | |
| Extended Interval | 45435 | 0.4* | ND | 0.49* | ND | ND |
| 45441 | 0.08* | ND | 0.33* | 0.19* | ND | |
| 45448 | ND | ND | ND | 0.17* | ND | |
| 3M-052-SE | 45838 | ND | ND | ND | ND | 0.11 |
| 45840 | ND | ND | ND | ND | 0.11 | |
| 45847 | ND | ND | ND | ND | 0.06 | |
| 45851 | ND | ND | ND | ND | 0.06 | |
*Average of 2–4 independent Ag+ B cell sorting experiment,
¶Oral LN consisted of axillary, mesenteric, submandibular, cervical, submental, and retropharyngeal LN, ND = No sort performed.