Table 4. Pharmacokinetic parameters for HLX10 in cynomolgus monkeys.

Dose mg/kg	Sex		t1/2	Cmax	AUClast	AUCinf	Vz	CL	MRT	Cmax	AUClast
			h	μg/mL	h*mg/mL	h*mg/mL	mL/kg	mL/h/kg	h	Ratio	Ratio
3	M	Mean	137.97	91.33	13.25	14.38	41.18	0.21	153.02	1.00	1.00
		SD	41.80	3.10	1.01	0.99	10.02	0.01	27.65
	F	Mean	159.21	89.07	14.45	15.75	43.56	0.19	169.49	1.00	1.00
		SD	40.49	3.26	0.43	1.31	9.84	0.02	36.78
10	M	Mean	256.99	318.64	63.33	75.92	48.47	0.13	231.28	3.49	4.78
		SD	56.13	20.86	2.79	9.70	4.43	0.02	15.66
	F	Mean	173.29	275.05	41.06	46.43	53.52	0.23	181.31	3.09	2.84
		SD	77.62	18.14	9.35	13.42	14.00	0.07	47.54
30	M	Mean	191.69	922.95	173.02	201.61	38.05	0.17	199.68	10.11	13.05
		SD	159.95	232.81	52.80	99.25	18.89	0.07	74.55
	F	Mean	178.78	862.52	160.81	179.56	39.21	0.18	194.16	9.68	11.13
		SD	120.96	246.71	34.06	53.69	20.32	0.06	73.85

Note: C_maxratio and AUC_last ratio are relative to the 3 mg/kg dose group data.