Table 1.
Heterologous production of PKS/NRPS‐derived natural products in M. xanthus.
| Compound | Native producer | Pathway type [size] | Promoter | Yield a | Ref |
|---|---|---|---|---|---|
| Alkypyrones | MCy9487 | PKS [6 kb] | Pvan | n.d. | Hug et al. (2019) |
| Argyrins A, B, I | Cystobacter sp. SBCb004 | NRPS [33 kb] | PnptII | 230 mg l−1 | Pogorevc et al. (2019b) |
| Argyrins A, B, I | Cystobacter sp. SBCb004 | NRPS [33 kb] | PnptII | 350–400 mg l−1 | This study |
| Argyrins A, B, I | Cystobacter sp. SBCb004 | NRPS [33 kb] | Pvan | 300 mg l−1 | This study |
| Argyrins A, B, I | Cystobacter sp. SBCb004 | NRPS [33 kb] | Pvan∆R | 250–300 mg l−1 | This study |
| Argyrins A, B, I | Cystobacter sp. SBCb004 | NRPS [33 kb] | Ptet | 50–100 mg l−1 | This study |
| Argyrins A, B, I | Cystobacter sp. SBCb004 | NRPS [33 kb] | Ptet∆R | 200–250 mg l−1 | This study |
| Argyrins A, B, I | Cystobacter sp. SBCb004 | NRPS [33 kb] | Ppm | 200 mg l−1 | This study |
| Bengamide | Myxococcus virescens | PKS/NRPS [25 kb] | PnptII | > 10 mg l−1 | Wenzel et al. (2015) |
| Corallopyronin A | Corallococcus coralloides | PKS/NRPS [65 kb] | PnptII | 37 mg l−1 | Sucipto et al. (2017) |
| Corallopyronin A | Corallococcus coralloides | PKS/NRPS [65 kb] | Pvan | 100 mg l−1 | Pogorevc et al. (2019a) |
| Cystobactamide Cys919‐1 | Cystobacter velatus Cbv34 | NRPS [52 kb] | Pvan | 8.1 mg l−1 | Groß et al. (2021) |
| Dawenol | Stigmatella aurantiaca | PKS [21 kb] | Native | n.d. | Oßwald et al. (2014) |
| Disorazol A2 | Sorangium cellulosum So ce12 | PKS/NRPS [58kb] | Ptet /Pcp25 | ~ 1 mg l−1 | Tu et al. (2016) |
| Epothilone | Sorangium cellulosum | PKS/NRPS [56 kb] | Native | 0.1–0.4 mg l−1 | Julien and Shah (2002); Lau et al. (2002); Oßwald et al. (2014) |
| Haliangicin | Haliangium ochraceum SMP‐2 | PKS [47.8 kb] | Native | 11 mg l−1 | Sun et al. (2016) |
| Myxochromide A | Myxococcus xanthus | PKS/NRPS [29 kb] | PnptII | ~ 500 mg l−1 | Yan et al. (2018b) |
| Myxochromide S | Stigmatella aurantiaca | PKS/NRPS [29 kb] | PnptII | > 500 mg l−1 | Fu et al. (2008) |
| Myxopyronin A | Myxococcus fulvus | PKS/NRPS [53 kb] | PnptII | 156 mg l−1 | Sucipto et al. (2017) |
| Myxothiazol | Stigmatella aurantiaca | PKS/NRPS [57 kb] | Ppm | 20 mg l−1 | Perlova et al. (2006) |
| Oxytetracycline | Streptomyces rimosus | PKS [32 kb] | Native | 10 mg l−1 | Stevens et al. (2010) |
| Pretubulysin | Cystobacter sp. | PKS/NRPS [40 kb] | Ptet | 0.2 mg l−1 | Chai et al. (2012) |
| PUFAs b | Aetherobacter fasciculatus | PKS/FAS [18 kb] | Ptet | ~ 1 mg CDW−1 | Gemperlein et al. (2014) |
| Pyxidicyclines | Pyxidicoccus fallax And48 | PKS [33 kb] | Pvan /PnptII | n.d. | Panter et al. (2018) |
| Vioprolide B, D | Cystobacter violaceus | NRPS [56 kb] | Ptet | 80 mg l−1 | Yan et al. (2018a) |
n.d., not determined.
a
Based on shake flask experiments.
b
Polyunsaturated fatty acids.