Table 1.
Demographic and health characteristics, early life characteristics and imaging characteristics of STRADL, the Dutch Famine Birth cohort, the LBC1936 and the Simpson’s cohort
| STRADL |
Dutch Famine |
LBC1936 |
Simpson’s |
|||||
|---|---|---|---|---|---|---|---|---|
| Total n | n (%) | Total n | n (%) | Total n | n (%) | Total n | n (%) | |
| Demographic and health characteristics | ||||||||
| Age (y) at MRI, mean (SD), range | 1080 | 59.3 (10.1), 26–84 | 118 | 67.5 (0.9), 65–69 | 685 | 72.7 (0.7), 71–74 | 110 | 78.4 (1.5), 75–81 |
| Sex, male | 1080 | 437 (40.5) | 118 | 52 (44.1) | 685 | 361 (52.7) | 110 | 33 (30) |
| Manual adult SES | 1070 | 345 (31.9) | 118 | 44 (37.3) | 674 | 141 (20.9) | 110 | 64 (58.2) |
| History of stroke | 1080 | 33 (3.1) | 117 | 3 (2.6) | 685 | 47 (6.9) | 110 | 16 (14.6) |
| Hypertension | 1080 | 299 (27.7) | 117 | 62 (53.0) | 685 | 336 (49.1) | 110 | 49 (44.6) |
| Diabetes | 1069 | 84 (7.9) | 118 | 24 (20.3) | 685 | 72 (10.5) | 110 | 7 (6.4) |
| Hypercholesterolemia | 930 | 221 (23.7) | 117 | 56 (47.9) | 685 | 287 (41.9) | – | – |
| Smoking history | 962 | 118 | 685 | 110 | ||||
| Ever smoker | 435 (40.3) | 72 (61.0) | 362 (52.9) | 60 (54.6) | ||||
| Never smoked | 527 (48.8) | 46 (39.0) | 323 (47.2) | 50 (45.5) | ||||
| Early life characteristics | ||||||||
| Years of birth | 1933–1993 | 1944–1947 | 1936 | 1921–1926 | ||||
| Median year 1955 | ||||||||
| Birth factors | ||||||||
| Ponderal index (kg/m3) mean (SD) | – | – | 115 | 26.2 (2.3) | 79 | 27.3 (5.3) | 107 | 25.8 (4.2) |
| Birth weight (g), mean (SD) | 154 | 3309.3 (529.4) | 118 | 3417.5 (503.4) | 140 | 3351.5 (482.1) | 110 | 3333.6 (457.2) |
| Low birth weight (<5lbs), n (%) | 253 | 6 (2.4) | – | – | – | – | – | – |
| Birth length (cm), mean (SD) | – | – | 118 | 51.9 (8.0) | 79 | 50.0 (3.3) | 107 | 50.7 (2.8) |
| Childhood factors | ||||||||
| Childhood IQ | 246 | 102.0 (8.9) | – | – | 648 | 100.8 (15.3) | 30 | 101.7 (14.5) |
| Low versus high level of educationa | 1078 | 259 (24.0) | 118 | 74 (62.7) | 685 | 491 (71.7) | 110 | 89 (80.9) |
| Manual father's occupation | 1070 | 719 (67.2) | 96 | 64 (66.7) | 627 | 465 (74.2) | 110 | 76 (69.1) |
| Imaging characteristics | ||||||||
| Visual ratings | ||||||||
| Total SVD score | 1058 | 114 | 680 | 96 | ||||
| 0 | 461 (43.6) | 52 (45.6) | 302 (44.4) | 12 (12.5) | ||||
| 1 | 414 (39.1) | 35 (30.7) | 249 (36.6) | 53 (55.2) | ||||
| 2 | 145 (13.7) | 16 (14.0) | 98 (14.4) | 20 (20.8) | ||||
| 3 | 31 (2.9) | 9 (6.0) | 27 (4.0) | 8 (8.3) | ||||
| 4 | 7 (0.7) | 2 (1.3) | 4 (0.6) | 3 (3.1) | ||||
| Mod/sev total SVD score | 1058 | 188 (17.3) | 114 | 27 (23.7) | 680 | 129 (19.0) | 97 | 31 (32.0) |
| Mod/sev WMH | 1075 | 114 (10.6) | 118 | 30 (25.4) | 685 | 154 (22.5) | 110 | 27 (24.6) |
| Mod/sev EPVS | 1063 | 511 (48.1) | 114 | 28 (24.6) | 680 | 276 (40.6) | 110 | 83 (75.5) |
| 1+ Lacune | 1076 | 86 (7.2) | 118 | 26 (22.0) | 680 | 33 (4.9) | 110 | 27 (24.5) |
| 1+ CMB | 1074 | 119 (11.1) | 117 | 16 (13.7) | 680 | 79 (11.6) | 97 | 11 (11.3) |
| Imaging evidence of 1+ infarcts | 1076 | 60 (5.0) | 118 | 22 (18.6) | 685 | 99 (14.5) | 110 | 10 (7.7) |
| Mod/sev atrophy | 1076 | 70 (5.8) | 118 | 23 (19.5) | 685 | 189 (27.6) | 110 | 64 (58.2) |
| Brain volumes | ||||||||
| Whole brain volume (mm3), mean (SD) | 882 | 1 064 225.8 (107 249.4) |
– | – | 657 | 990 322.7 (89 401.9) | 110 | 1 137 480.3 (98 056.8) |
| ICV (mm3), mean (SD) | 893 | 1 376 151.5 (226471.3) |
– | – | 659 | 1 438 223.1 (133 870.1) | 95 | 1 454 751.50 (123 117.80) |
| WMH volume (mm3), median (IQR) | 471 | 1510.0 (2942.5) | – | – | 656 | 7896.0 (11 531.0) | 107 | 25 755.4 (27 166.0) |
A dash is used where data are not available; mod/sev WMH = periventricular WMH with a score of 3 and/or deep WMH with a score of 2–3 on the Fazekas scale34; mod/sev EPVS = moderate or severe enlarged perivascular spaces; a score of 2–3 on a semi-quantitative scale in the basal ganglia35; CMB = cerebral microbleed.
a
Low education defined as compulsory education and below (STRADL), lower secondary school and below (Dutch Famine Birth Cohort) and 11 years and below (LBC1936 and Simpson’s cohort).