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. 2021 Sep 28;144(12):3674–3691. doi: 10.1093/brain/awab356

Figure 8.

Figure 8

Correlative PARIS phosphorylation and MDM4 repression in Parkinson’s disease pathogenesis. (A, C and E) Expression of PARIS, pY137-PARIS and MDM4 in post-mortem cortical sections from Parkinson’s disease patients with cortical Lewy body pathologies and age-matched controls monitored by immunofluorescence using specific antibodies and the nuclear counterstain DAPI. Scale bar = 10 µm. (B, D and F) Quantification of the relative fluorescent intensities of cells from the post-mortem brain tissue sections of Parkinson’s disease patients and age-matched controls (n = 6 control and 6 Parkinson’s disease). (G) Correlation plots and Pearson correlation analysis of pY137-PARIS and MDM4 expression in the post-mortem cortex of Parkinson’s disease patients and age-matched healthy control subjects. Data are expressed as mean ± SEM. ***P < 0.001. Statistical analysis was performed using an unpaired two-tailed Student’s t-test. PD = Parkinson’s disease.