Fig. 6.

The ribosome surface acts as a molecular chaperone. Positively charged and aromatic residues within the NC interact with the highly negatively charged ribosome surface. Negatively charged regions create a repulsion with the ribosome surface and are highly dynamic. In some cases, negatively charged residues are seen to interact with the negatively charged ribosome surface via the Mg²⁺ ion shell surrounding the ribosome. The molecular chaperone, TF, also preferentially interacts with positively charged and aromatic residues within the NC. A handover from the ribosome surface to the molecular chaperone is likely to occur during NC elongation.