Table 3.
Unadjusted and Adjusted Estimates for Predicting Longitudinal Changes in Quality of Life Scores
| Unadjusted Estimates | Adjusted Estimates | |||
|---|---|---|---|---|
| Mean Difference in PAGI-QOL over 6-Months (95% CI) | P-value | Mean Difference in PAGI-QOL over 6-Months (95% CI) | P-value | |
| Variables Associated with Improvement in Quality of Life Scores Over Time | ||||
| Male gender | 0.43 (−0.07, 0.92) | .09 | 0.71 (0.27, 1.15) | .002 |
| BSFS (per every 1-unit increase) | 0.06 (−0.007, 0.12) | .08 | 0.05 (−0.01, 0.11) | <.10 |
| BMI < 18 (compared to 18 ≤ BMI ≤ 30) | 0.42 (0.03, 0.81) | .03 | ||
| Variables Associated with Worsening of Quality of Life Scores Over Time | ||||
| Opioid use | −0.47 (−1.00, 0.05) | .06 | −0.51 (−0.98, −0.04) | .03 |
| BMI > 30 (compared to 18 ≤ BMI ≤ 30) | −0.38 (−0.78, 0.02) | .06 | −0.54 (−0.93, −0.15) | .007 |
| Meets Rome III criteria for FD | −0.63 (−1.04, −0.22) | .003 | ||
| Meets Rome III criteria for N/V/belching disorders | −0.32 (−0.69, 0.06) | <.10 | ||
| Delayed GES | −0.53 (−0.94, −0.12) | .01 | ||
| Delayed GET | −0.31 (−0.66, 0.05) | .09 | −0.46 (−0.82, −0.10) | .01 |
| Gastric Ct below 25th percentile (< 27) (compared to Ct between 25th and 75th percentile) | −0.54 (−0.95, −0.13) | .01 | ||
| Gastric MI below 25th percentile (< 10.1) (compared to MI between 25th and 75th percentile) | −0.54 (−0.97, −0.12) | .01 | −0.81 (−1.26, −0.36) | .0004 |
| Small bowel MI above 75th percentile (> 13.8) (compared to MI between 25th and 75th percentile) | −0.39 (−0.82, 0.05) | .08 | −0.62 (−1.03, −0.22) | .003 |
BMI, body mass index (kg/m2); BSFS, Bristol stool form scale; Ct, contraction frequency; FD, functional dyspepsia by Rome III criteria; GES, gastric emptying scintigraphy; GET, gastric emptying time measured by wireless motility capsule; MI, motility index; PAGI-QOL, patient assessment of upper gastrointestinal disorders-quality of life.