Table 2.
Heterogeneity test.
| CDKAL1 | Group | A fixed-effects model | A random-efforts model | Heterogeneity | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | Z | p | OR (95% CI) | z | p | X 2 | I 2 (%) | PQ test | ||
| A vs. C | Total | 0.89 [0.86, 0.92] | 6.17 | p < 0.00001 | 0.85 [0.77, 0.94] | 3.25 | p = 0.001 | 76.82 | 83% | p < 0.00001 |
| Asian | 0.92 [0.88, 0.97] | 3.36 | p = 0.008 | 0.87 [0.75, 1.02] | 1.73 | p = 0.08 | 65.37 | 89% | p < 0.00001 | |
| Non-Asian | 0.83 [0.78, 0.88] | 5.88 | p < 0.00001 | 0.83 [0.77, 0.88] | 5.55 | p < 0.00001 | 5.59 | 11% | p = 0.35 | |
|
| ||||||||||
| AA vs. AC+CC | Total | 0.77 [0.73, 0.82] | 9.15 | p < 0.00001 | 0.77 [0.70, 0.85] | 5.42 | p < 0.00001 | 149.89 | 92% | p < 0.00001 |
| Asian | 0.83 [0.77, 0.88] | 7.68 | p < 0.00001 | 0.75 [0.64, 0.88] | 3.61 | p = 0.0003 | 29.52 | 76% | p = 0.0001 | |
| Non-Asian | 0.79 [0.72, 0.86] | 4.99 | p < 0.00001 | 0.79 [0.72, 0.87] | 4.97 | p < 0.00001 | 84.86 | 96% | p = 0.58 | |
|
| ||||||||||
| AA+AC vs. CC | Total | 0.86 [0.80, 0.92] | 4.47 | p < 0.00001 | 0.81 [0.69, 0.94] | 2.68 | p = 0.007 | 33.42 | 61% | p = 0.001 |
| Asian | 0.91 [0.83, 0.99] | 2.23 | p = 0.03 | 0.85 [0.66, 1.10] | 1.21 | p = 0.23 | 59.98 | 86% | p < 0.00001 | |
| Non-Asian | 0.78 [0.70, 0.87] | 4.39 | p < 0.0001 | 0.78 [0.70, 0.87] | 4.38 | p < 0.0001 | 1.70 | 0 | p < 0.00001 | |