Table 3.

Cox multivariable analyses and the incremental value of cardiovascular magnetic resonance diagnosis for the prediction of all-cause death

Covariates	All patients (n = 903)		Patients without extracardiac malignancy (n = 617)		Patients with extracardiac malignancy (n = 286)
	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
Age (per 5-year increase)	1.09 (1.04–1.13)	<0.001	1.15 (1.08–1.22)	<0.001	1.04 (0.98–1.10)	0.20
Male sex	1.10 (0.88–1.37)	0.40	1.13 (0.81–1.59)	0.47	1.15 (0.85–1.55)	0.37
Hypertension	1.02 (0.80–1.30)	0.87	0.91 (0.63–1.32)	0.63	1.09 (0.78–1.52)	0.61
Hyperlipidaemia	0.80 (0.63–1.02)	0.07	0.68 (0.48–0.95)	0.026	0.95 (0.68–1.34)	0.78
Diabetes	1.22 (0.94–1.59)	0.13	1.31 (0.92–1.86)	0.13	0.96 (0.63–1.45)	0.84
Smoking	1.37 (1.11–1.69)	0.004	1.50 (1.09–2.06)	0.013	1.39 (1.03–1.87)	0.029
Coronary artery disease	1.17 (0.91–1.51)	0.22	1.21 (0.83–1.76)	0.32	1.15 (0.80–1.65)	0.46
CMR LVEF (per 5% decrease)	1.05 (1.01–1.10)	0.019	1.09 (1.03–1.15)	0.005	1.02 (0.95–1.09)	0.58
Extracardiac malignancy	2.32 (1.81–2.97)	<0.001	—	—	—	—
CMR diagnosis—no mass	Reference	NA	Reference	NA	Reference	NA
CMR diagnosis—pseudomass	1.03 (0.70–1.51)	0.90	1.02 (0.63–1.65)	0.93	0.98 (0.51–1.91)	0.96
CMR diagnosis—thrombus	1.46 (1.00–2.11)	0.048	1.45 (0.90–2.35)	0.13	1.18 (0.64–2.18)	0.59
CMR diagnosis—benign tumour	0.77 (0.50–1.17)	0.22	0.79 (0.47–1.31)	0.36	0.81 (0.38–1.76)	0.60
CMR diagnosis—malignant tumour	3.31 (2.40–4.57)	<0.001	5.40 (3.38–8.63)	<0.001	2.28 (1.45–3.57)	<0.001
Incremental value testing
	χ  2	P-value	χ  2	P-value	χ  2	P-value
Clinical model	215.8	<0.001	49.6	<0.001	18.8	0.02
Clinical model with CMR diagnosis	299.8	<0.001	106.9	<0.001	45.2	<0.001
Likelihood ratio test comparing models with and without CMR diagnosis	<0.001		<0.001		<0.001

CI, confidence interval; CMR, cardiovascular magnetic resonance; HR, hazard ratio; LVEF, left ventricular ejection fraction; NA, Not applicable. P-values in bold are <0.05.