Table 1.

Comparison of animal models of aortic aneurysm.

Model	Advantages	Limitations	Severity	Mechanism	Rupture	Dissection	Positive risk factors of AAA in humans
Angiotensin II perfusion [10,11]	Commonly used model, cause of technical ease Possibility to use hyperlipidemic mice Formation along the aorta	The predominant pathology is aortic dissection and intramural hematoma Used only in mice	Moderate	Independent of changes in blood pressure, Ang II causes an inflammatory reaction in the artery wall	Yes	Yes	Male sex Smoking Dyslipidemia Arteriosclerosis IMT (intramural thrombus)
Elastase perfusion [10,11]	Commonly used Enlargement of aorta occurs fast and in the segment of elastase perfusion Occurs expansion of whole wall of the aorta (unlike in usage of Ang II)	Technically difficult Surgery requires special equipment	Moderate	Inflammation Calcification	No	No	Male sex Smoking ILT (intraluminal thrombus)
Calcium chloride or phosphate usage [10,11]	Involved in mostly in acute injury of aorta Can be used on different animal species Induced without atherectomy	Technically difficult Surgery requires special equipment	Mild	Inflammation Calcification	No	No	Dyslipidemia
Xenograft [5]	Controlling of the immune response Intraluminal thrombus is common	Technically difficult Surgery requires special equipment	Severe	Inflammation	Yes	Yes	Not reported