Table 2.
Groups | Treatments | Dose mg/kg | Paw edema at different time intervals | %age inhibition of edema | ||||
---|---|---|---|---|---|---|---|---|
1 h | 2 h | 3 h | 1 h | 2 h | 3 h | |||
1 | DMSO | 10 ml/kg | 1.267 ± 0.02 | 1.417 ± 0.031 | 1.640 ± 0.040 | 0 | 0 | 0 |
2 | Ibuprofen | 100 | 0.617 ± 0.048** | 0.433 ± 0.067*** | 0.367 ± 0.033*** | 51% | 69% | 78% |
3 | 3 | 25 | 0.733 ± 0.067* | 0.583 ± 0.07** | 0.583 ± 0.070*** | 42% | 59% | 64% |
4 | 50 | 0.567 ± 0.049** | 0.45 ± 0.043*** | 0.45 ± 0.050*** | 55% | 68% | 72% | |
5 | 75 | 0.383 ± 0.031*** | 0.3 ± 0.037*** | 0.250 ± 0.022*** | 70% | 79% | 85% | |
6 | 5 | 50 | 0.783 ± 0.03* | 0.650 ± 0.076** | 0.533 ± 0.056*** | 38% | 54% | 67% |
7 | 75 | 0.5 ± 0.04** | 0.5 ± 0.037*** | 0.483 ± 0.054*** | 60% | 65% | 70% | |
8 | 100 | 0.417 ± 0.065*** | 0.417 ± 0.031*** | 0.317 ± 0.031*** | 67% | 71% | 81% |
Note. One way ANOVA as applied to compare the activity of control and test compound treated groups. (n = 6)
*significant inhibition of paw edema (P < 0.05)
**Very significant inhibition of paw edema (P < 0.01)
***highly significant inhibition of paw edema (P < 0.001)