Table 3.
Treatments | Doses mg/kg (i.p) | No of wriths | % age inhibition |
---|---|---|---|
3 | 25 | 38.33 ± 2.679** | 53% |
50 | 27.66 ± 1.80*** | 66.83% | |
75 | 14.0 ± 0.856*** | 83% | |
5 | 50 | 47.66 ± 2.90* | 41.83% |
75 | 36.66 ± 1.978** | 55.30% | |
100 | 24.83 ± 1.759*** | 70% | |
Ibuprofen | 100 | 23.5 ± 1.05*** | 71.5% |
DMSO(10 ml/kg) | 83.33 ± 3.37 | 0 |
% age inhibition of wriths in mice in all groups showing analgesic activity of synthetic test compounds. Data expressed as mean ± SEM, one-way ANOVA followed by post Dunnett’s test, n = 6
*Significant inhibition of nociceptive response (P < 0.05)
**very significant inhibition of nociceptive response (P < 0.01)
***Highly significant inhibition of nociceptive response (P < 0.001)