Table 1.
Effects of tartrazine and the natural dye (COL) on some parameters of oxidative stress in the mammary glands and tumors
| NOR | NOR + TARZ | DMBA | DMBA + TARZ | DMBA + COL | |
|---|---|---|---|---|---|
| • MDA (mM/mg de protéines) | 4.37 ± 0.13 | 4.7 ± 0.92 | 4.4 ± 0.24 | 6.2 ± 0.53**## | 4.92 ± 0.51 |
| • SOD (unité/mg de protéines) | 108.5 ± 0.74 | 116.1 ± 0.31 | 95.1 ± 0.13 | 74.9 ± 0.22**## | 111.52 ± 0.54 |
| • Catalase (mM de H2O2/min/mg de protéines) | 0.71 ± 0.02 | 0.68 ± 0.04 | 0.46 ± 0.02# | 0.23 ± 0.02**## | 0.48 ± 0.03 |
| • GSH (mM/mg de protéines) | 0.01 ± 0.0017 | 0.01 ± 0.0004 | 0.008 ± 0.0002 | 0.006 ± 0.000## | 0.016 ± 0.0004 |
NOR Animals serving as normal control receiving distilled water, NOR + TARZ Animals receiving tartrazine only, DMBA Animals serving as negative control receiving distilled water, DMBA + TARZ Animals receiving tartrazine at a dose of 50 mg/kg BW, DMBA + COL Animals receiving a natural dye at a dose of 50 mg/kg. #p < 0.05; ## p < 0.01 compared to the NOR group; ** p < 0.01 compared to the DMBA group