Table 1:
Characteristics of 1121 women recruited at a primary care site (screening population) and at a colposcopy clinic (referral population) in Cape Town, South Africa, by HIV status
| Screening Population recruited at Primary Care Site | Referral Population recruited at Colposcopy Clinic | |||
|---|---|---|---|---|
| HIV-negative (n=382) | HIV-positive (n=333) | HIV-negative (n=204) | HIV-positive (n=202) | |
| Histological confirmed disease: | ||||
| Within Normal Limits | 330 (86.4) | 229 (68.8) | 80 (39.2) | 40 (19.8) |
| CIN11 | 28 (7.3) | 45 (13.5) | 14 (6.9) | 43 (21.3) |
| CIN2 | 8 (2.1) | 28 (8.4) | 23 (11.3) | 38 (18.8) |
| CIN3 | 10 (2.6) | 23 (6.9) | 71 (34.8) | 74 (36.6) |
| Squamous cell carcinoma | 2 (0.5) | 4 (1.2) | 9 (4.4) | 5 (2.5) |
| Adenocarcinoma in situ | 0 | 1 (0.3) | 1 (0.5) | 0 |
| No histology result | 4 (1.0) | 3 (0.9) | 6 (2.9) | 2 (1.0) |
| HPV Xpert result | ||||
| Any of the 5 channels positive2 | 62 (16.2) | 161 (48.4) | 151 (74.0) | 182 (90.6) |
| HPV Xpert result | ||||
| 0 of 3 selected3 channels positive | 331 | 196 | 58 | 244 |
| 1 of 3 selected channels positive | 45 (11.8) | 98 (29.4) | 119 (58.3) | 127 (63.2) |
| 2 or 3 of selected channels positive | 6 (1.6) | 39 (11.7) | 27 (13.2) | 50 (24.9) |
| Median age in years (IQR) | 44 (37 – 52) | 39 (35 – 46) | 40 (34 – 50) | 38 (34 – 44) |
| Median parity (IQR) | 3 (2 – 4) | 2 (1 – 3) | 2 (2 – 3) | 2 (1 – 3) |
| Any prior screening | 246 (64.0) | 249 (74.8) | 204 (100) | 202 (100) |
| Age at first pregnancy | ||||
| Never pregnant | 9 (2.4) | 15 (4.5) | 4 (2.0) | 6 (3.0) |
| ≤16 years | 43 (11.3) | 40 (12.0) | 26 (12.7) | 26 (12.9) |
| >16 years | 330 (86.4) | 278 (83.5) | 174 (85.3) | 170 (84.1) |
| Tobacco use | ||||
| Current | 42 (11.0) | 38 (11.4) | 60 (29.4) | 16 (7.9) |
| Former | 20 (5.2) | 16 (4.8) | 19 (9.3) | 11 (5.5) |
| Never | 320 (83.8) | 279 (83.8) | 125 (61.3) | 175 (86.6) |
| On antiretroviral therapy | ||||
| Yes | N/A | 266 (79.9) | N/A | 178 (88.1) |
| No | 67 (20.1) | 24 (11.9) | ||
1.
Abbreviation: Cervical intraepithelial neoplasia grade 1 (CIN1), grade 2 (CIN2) or grade 3 (CIN3)
2.
Positive for HPV 16, and/or HPV 18, 45, and/or HPV 31, 33, 35, 52, 58, and/or HPV 51, 59, and/or HPV 39, 56, 66 68.
3.
Positive for HPV 16, and/or HPV 18, 45, and/or HPV 31, 33, 35, 52, 58.
4.
One woman in this group had an invalid HPV result was excluded.