Table 2:
Sensitivity, specificity, positive and negative predictive values and screen-positive rates (as percentages) in the study populations1
| Sensitivity (95% CI) | Specificity (95% CI) | Positive Predictive Value (95% CI) | Negative Predictive Value (95% CI) | Screen positive Rate (95% CI) | |
|---|---|---|---|---|---|
| CIN2+ | |||||
| HIV-negative | N=124 | N=358 | N=358 | ||
| Any of the 5 high risk channels2 | 88.7 (83.1–94.3) | 86.9 (83.4–90.4) | 23.0 (12.4–33.5) | 98.1 (96.6–99.6) | 16.1 (12.4–19.9) |
| Selected 3 channels3 | 87.1 (81.2–93.0) | 89.7 (86.5–92.8) | 27.5 (15.2–39.7) | 98.2 (96.7–99.6) | 13.5 (10.0–16.9) |
| HIV-positive | N=1724 | N=273 | N=273 | ||
| Any of the 5 high risk channels2 | 93.6 (90.0–97.3) | 59.9 (54.1–65.7) | 31.7 (24.5–38.9) | 97.0 (94.5–99.6) | 48.8 (43.4–54.2) |
| Selected 3 channels3 | 90.7 (86.4–95.0) | 67.5 (62.0–73.1) | 35.0 (27.0–43.0) | 95.9 (93.0–98.7) | 41.5 (36.2–46.8) |
| CIN3+ | |||||
| HIV-negative | N=93 | N=366 | N=366 | ||
| Any of the 5 high risk channels2 | 93.6 (88.6–98.5) | 86.3 (82.8–89.9) | 18.0 (8.4–27.7) | 99.7 (99.1–100) | 16.1 (12.4–19.9) |
| Selected 3 channels3 | 91.4 (85.7–97.1) | 89.1 (85.9–92.3) | 21.6 (10.3–32.9) | 99.7 (99.1–100) | 13.5 (10.0–16.9) |
| HIV-positive | N=106 | N=301 | N=301 | ||
| Any of the 5 high risk channels2 | 95.3 (91.3–99.3) | 55.6 (50.0–61.2) | 16.8 (11.0–22.5) | 99.4 (98.3–100) | 48.8 (43.4–54.2) |
| Selected 3 channels3 | 93.4 (88.7–98.1) | 63.3 (57.8–68.7) | 19.0 (12.4–25.5) | 99.0 (97.5–100) | 41.5 (36.2–46.8) |
1.
By design, sensitivity is calculated combining data from the screening and referral study populations, and specificity, positive and negative predictive value and percent screen-positive from the screening population only.
2.
Positive for HPV 16, and/or HPV 18, 45, and/or HPV 31, 33, 35, 52, 58, and/or HPV 51, 59, and/or HPV 39, 56, 66 68.
3.
Positive for HPV 16, and/or HPV 18, 45, and/or HPV 31, 33, 35, 52, 58.
4.
One woman with an invalid HPV result was excluded from this group.