Table 3:
Sensitivity, specificity positive and negative predictive values, and screen-positive rates by HIV status utilizing different cycle threshold (Ct) cut-offs from the three channels on HPV Xpert detecting HPV 16, 18, 45, 31, 33, 35, 52, 58
| Sensitivity | Specificity | Positive Predictive Value (95% CI) | Negative Predictive Value (95% CI) | Screen positive (95% CI) | |
|---|---|---|---|---|---|
| CIN2+ | |||||
| HIV-negative | |||||
| 65 | 96.4 | 50.0 (42.3–57.7) | 98.0 (96.5–99.5) | 6.9 (4.5–9.2) | |
| 70 | 96.4 | 51.9 (33.3–59.5) | 98.3 (97.0–99.7) | 7.1 (4.7–9.5) | |
| 75 | 95.3 | 47.2 (40.2–54.2) | 98.6 (97.4–99.8) | 8.4 (5.7–11.1) | |
| 80 | 94.1 | 43.1 (36.7–49.5) | 98.8 (97.6–100) | 9.8 (6.9–12.8) | |
| 85 | 91.3 | 35.4 (30.0–40.8) | 99.1 (98.1–100) | 12.7 (9.3–16.1) | |
| HIV-positive | |||||
| 65 | 88.3 | 53.3 (46.6–60.1) | 92.5 (89.3–95.7) | 20.7 (16.5–25.0) | |
| 70 | 87.2 | 52.9 (46.4–59.4) | 93.4 (90.4–96.4) | 22.5 (18.0–27.0) | |
| 75 | 85.8 | 52.0 (45.8–58.2) | 94.4 (91.5–97.3) | 24.5 (19.8–29.2) | |
| 80 | 83.2 | 49.4 (43.5–55.3) | 95.3 (92.6–98.0) | 27.5 (22.5–32.5) | |
| 85 | 77.0 | 43.1 (37.8–48.4) | 96.2 (93.7–98.7) | 33.5 (28.1–39.0) | |
| CIN3+ | |||||
| HIV-negative | |||||
| 65 | 96.7 | 39.6 (31.8–47.4) | 98.8 (97.7–99.9) | 5.3 (3.1–7.4) | |
| 70 | 95.9 | 36.2 (29.7–43.2) | 99.0 (98.0–100) | 6.2 (3.8–8.5) | |
| 75 | 95.1 | 33.7 (27.3–40.1) | 99.2 (98.3–100) | 7.2 (4.6–9.6) | |
| 80 | 93.4 | 29.0 (23.4–34.6) | 99.4 (98.8–100) | 8.9 (6.1–11.8) | |
| 85 | 92.3 | 28.4 (23.1–33.7) | 99.5 (98.8–100) | 9.6 (7.1–13.2) | |
| HIV-positive | |||||
| 65 | 88.4 | 34.2 (27.7–40.8) | 96.5 (94.3–98.7) | 16.1 (12.2–20.1) | |
| 70 | 87.1 | 33.7 (27.5–40.0) | 97.0 (95.0–99.0) | 17.8 (13.6–21.9) | |
| 75 | 86.1 | 33.5 (27.5–39.5) | 97.4 (95.5–99.3) | 19.1 (14.8–23.4) | |
| 80 | 84.8 | 32.8 (27.1–38.5) | 97.9 (96.2–99.6) | 20.7 (16.2–25.2) | |
| 85 | 74.8 | 24.0 (19.7–28.3) | 98.3 (96.6–99.9) | 30.3 (25.1–35.5) |