Table 3.
Lens preferred genes differentially expressed in aged lens fibers
| SYMBOL | DESCRIPTION | Aged fibers versus Young fibers fold change | Aged fibers versus Young fibers FDR | Young fibers FPKM | Aged fibers FPKM | P56 fold lens enrichment |
|---|---|---|---|---|---|---|
| Wdfy4 | WD repeat and FYVE domain containing 4 | −99.3 | 6.2E-12 | 3.0 | 0.0 | 13.6 |
| Crygf | crystallin, gamma F | −56.0 | 7.3E-3 | 6469.7 | 115.6 | 271.9 |
| Crygb | crystallin, gamma B | −50.9 | 3.7E-3 | 25498.4 | 501.1 | 1644.0 |
| Cryga | crystallin, gamma A | −49.7 | 2.2E-2 | 255.2 | 5.1 | 595.9 |
| Crygd | crystallin, gamma D | −46.7 | 5.9E-3 | 22784.3 | 487.7 | 1640.6 |
| Crygc | crystallin, gamma C | −43.8 | 1.7E-3 | 23495.1 | 535.8 | 1644.0 |
| Chrng | cholinergic receptor, nicotinic, gamma | −34.2 | 5.8E-19 | 4.7 | 0.1 | 2.3 |
| Gp2 | glycoprotein 2 (zymogen granule membrane) | −33.2 | 3.0E-5 | 5.0 | 0.1 | 13.4 |
| Pgam2 | phosphoglycerate mutase 2 | −30.0 | 1.6E-6 | 335.5 | 11.2 | 7.8 |
| 1700020N01Rik | RIKEN cDNA 1700020N01 gene | −14.9 | 1.2E-6 | 12.7 | 0.8 | 65.2 |
| Ceacam10 | carcinoembryonic antigen-related cell adhesion molecule 10 | −14.4 | 2.8E-4 | 8.4 | 0.6 | 33.8 |
| Tcp11 | t-complex protein 11 | −13.7 | 7.6E-12 | 148.8 | 10.9 | 39.7 |
| Crybb3 | crystallin, beta B3 | −11.8 | 6.4E-23 | 10176.2 | 864.0 | 316.5 |
| Zfp354b | zinc finger protein 354B | −11.2 | 7.1E-8 | 8.2 | 0.7 | 14.2 |
| E130119H09Rik | RIKEN cDNA E130119H09 gene | −11.1 | 4.6E-6 | 52.6 | 4.7 | 16.5 |
| Pgap2 | post-GPI attachment to proteins 2 | −10.7 | 6.0E-64 | 19.9 | 1.9 | 22.2 |
| Snx22 | sorting nexin 22 | −9.5 | 1.1E-8 | 76.0 | 8.0 | 16.4 |
| Birc7 | baculoviral IAP repeat-containing 7 (livin) | −9.2 | 1.1E-5 | 295.7 | 32.0 | 66.5 |
| C920006O11Rik | RIKEN cDNA C920006O11 gene | −8.8 | 1.5E-7 | 7.1 | 0.8 | 43.3 |
| Ankrd24 | ankyrin repeat domain 24 | −8.5 | 6.6E-25 | 20.1 | 2.4 | 42.8 |
| Hspb1 | heat shock protein 1 | −8.1 | 4.8E-8 | 2679.5 | 330.3 | 34.7 |
| Crygn | crystallin, gamma N | −8.0 | 3.9E-15 | 157.4 | 19.9 | 191.3 |
| Ces5a | carboxylesterase 5A | −7.5 | 1.6E-4 | 60.5 | 8.0 | 26.8 |
| Rnf180 | ring finger protein 180 | −7.1 | 1.1E-25 | 29.0 | 4.1 | 87.1 |
| Rsph10b | radial spoke head 10 homolog B (Chlamydomonas) | −7.0 | 4.0E-53 | 44.5 | 6.3 | 114.4 |
| Pla2g7 | platelet-activating factor acetylhydrolase, plasma | −6.6 | 1.8E-9 | 8.2 | 1.3 | 3.2 |
| Stxbp6 | syntaxin binding protein 6 (amisyn) | −6.0 | 4.3E-11 | 5.2 | 0.9 | 2.8 |
| Gm4850 | predicted pseudogene 4850 | −5.8 | 4.2E-2 | 10.8 | 1.8 | 24.5 |
| Metrnl | meteorin, glial cell differentiation regulator-like | −5.7 | 1.7E-43 | 133.2 | 23.5 | 61.8 |
| Cela1 | chymotrypsin-like elastase family, member 1 | −5.7 | 5.1E-24 | 34.7 | 6.1 | 90.4 |
| Stx11 | syntaxin 11 | −5.4 | 7.2E-10 | 12.8 | 2.4 | 20.2 |
| Lgi2 | leucine-rich repeat LGI family, member 2 | −5.2 | 4.2E-22 | 5.6 | 1.1 | 5.3 |
| Clic5 | chloride intracellular channel 5 | −5.0 | 7.1E-8 | 31.2 | 6.2 | 63.1 |
| Crybb1 | crystallin, beta B1 | −4.9 | 1.1E-10 | 10608.6 | 2162.6 | 386.7 |
| Lim2 | lens intrinsic membrane protein 2 | −4.7 | 1.8E-2 | 12.3 | 2.6 | 350.2 |
| Ngef | neuronal guanine nucleotide exchange factor | −4.7 | 7.3E-12 | 68.7 | 14.7 | 38.6 |
| Cryba4 | crystallin, beta A4 | −4.4 | 8.6E-6 | 19980.3 | 4564.6 | 1083.9 |
| Aldh1a3 | aldehyde dehydrogenase family 1, subfamily A3 | −4.2 | 1.4E-5 | 2.8 | 0.7 | 3.0 |
| Hmox1 | heme oxygenase 1 | −4.1 | 6.3E-5 | 698.6 | 170.7 | 33.1 |
| Crygs | crystallin, gamma S | −4.1 | 2.9E-9 | 23770.5 | 5861.1 | 1525.4 |
| Bfsp1 | beaded filament structural protein 1, in lens-CP94 | −4.0 | 1.9E-15 | 12416.0 | 3101.2 | 507.8 |
| Slc7a5 | solute carrier family 7 member 5 | −3.9 | 8.8E-24 | 19.0 | 4.9 | 2.2 |
| Lrrc66 | leucine rich repeat containing 66 | −3.7 | 9.0E-14 | 8.9 | 2.4 | 13.7 |
| Gadd45b | growth arrest and DNA-damage-inducible 45 beta | −3.7 | 5.4E-12 | 24.3 | 6.6 | 6.9 |
| Cryba1 | crystallin, beta A1 | −3.5 | 1.4E-7 | 13744.0 | 3952.3 | 993.9 |
| Cryba2 | crystallin, beta A2 | −3.4 | 9.96E-10 | 14290.4 | 4219.9 | 828.3 |
| Pappa | pregnancy-associated plasma protein A | −3.2 | 4.9E-17 | 7.9 | 2.5 | 5.9 |
| Cryaa | crystallin, alpha A | −3.1 | 2.1E-12 | 57208.0 | 18646.8 | 867.1 |
| Eif5b | eukaryotic translation initiation factor 5B | −3.1 | 3.1E-20 | 289.0 | 94.7 | 20.0 |
| Crybb2 | crystallin, beta B2 | −3.0 | 3.9E-9 | 90716.5 | 30042.2 | 651.2 |
| Fas | Fas (TNF receptor superfamily member 6) | −3.0 | 5.9E-13 | 27.7 | 9.3 | 30.6 |
| Sh3bgr | SH3-binding domain glutamic acid-rich protein | −2.8 | 1.5E-10 | 29.0 | 10.3 | 13.5 |
| Cryab | crystallin, alpha B | −2.8 | 2.0E-15 | 13162.1 | 4685.7 | 176.6 |
| Hsf4 | heat shock transcription factor 4 | −2.8 | 2.0E-5 | 149.0 | 53.2 | 8.1 |
| Grifin | galectin-related inter-fiber protein | −2.8 | 3.6E-13 | 1143.0 | 408.7 | 288.4 |
| Entpd1 | ectonucleoside triphosphate diphosphohydrolase 1 | −2.8 | 4.3E-6 | 36.6 | 13.3 | 28.4 |
| Fgfrl1 | fibroblast growth factor receptor-like 1 | −2.7 | 2.0E-15 | 26.5 | 9.8 | 3.4 |
| Mip | major intrinsic protein of lens fiber | −2.7 | 2.2E-5 | 3103.0 | 1150.6 | 1282.7 |
| Fxyd1 | FXYD domain-containing ion transport regulator 1 | −2.6 | 2.4E-16 | 43.7 | 16.6 | 14.3 |
| Casp7 | caspase 7 | −2.6 | 7.3E-12 | 13.0 | 4.9 | 3.8 |
| Ninj1 | ninjurin 1 | −2.6 | 1.4E-7 | 17.8 | 6.9 | 8.1 |
| Pcbd2 | pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | −2.6 | 1.9E-11 | 212.5 | 83.1 | 14.3 |
| P4ha1 | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide | −2.5 | 2.4E-16 | 105.8 | 41.6 | 9.7 |
| Sned1 | sushi, nidogen and EGF-like domains 1 | −2.5 | 1.3E-4 | 3.3 | 1.3 | 5.7 |
| Mypn | myopalladin | −2.5 | 1.8E-5 | 51.3 | 20.4 | 34.8 |
| Pacsin3 | protein kinase C and casein kinase substrate in neurons 3 | −2.5 | 1.0E-11 | 121.5 | 48.6 | 22.9 |
| Ing2 | inhibitor of growth family, member 2 | −2.5 | 3.2E-13 | 100.7 | 40.3 | 13.6 |
| Dmrta2 | doublesex and mab-3 related transcription factor like A2] | −2.4 | 1.9E-13 | 35.5 | 14.5 | 15.4 |
| Zfp385a | zinc finger protein 385A | −2.4 | 1.5E-10 | 75.7 | 31.5 | 2.8 |
| Bfsp2 | beaded filament structural protein 2, phakinin | −2.3 | 2.1E-6 | 5196.8 | 2218.4 | 181.0 |
| Snta1 | syntrophin, acidic 1 | −2.3 | 6.7E-18 | 63.5 | 27.3 | 20.1 |
| Caprin2 | caprin family member 2 | −2.3 | 9.0E-4 | 13.0 | 5.6 | 14.7 |
| Ell2 | elongation factor RNA polymerase II 2 | −2.3 | 1.4E-10 | 24.2 | 10.6 | 11.5 |
| Nlrc5 | NLR family, CARD domain containing 5 | −2.2 | 1.8E-4 | 6.0 | 2.7 | 5.8 |
| Aldh1a7 | aldehyde dehydrogenase family 1, subfamily A7 | −2.2 | 9.9E-3 | 5.5 | 2.5 | 45.8 |
| S100a6 | S100 calcium binding protein A6 (calcyclin) | −2.2 | 4.0E-17 | 255.2 | 115.5 | 42.6 |
| Tom1 | target of myb1 trafficking protein | −2.2 | 1.1E-7 | 22.8 | 10.3 | 5.8 |
| Smco3 | single-pass membrane protein with coiled-coil domains 3 | −2.1 | 2.7E-4 | 65.6 | 31.1 | 199.5 |
| Tdrd7 | tudor domain containing 7 | −2.1 | 6.6E-6 | 557.9 | 265.3 | 92.8 |
| Dhx32 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | −2.1 | 8.3E-11 | 152.6 | 74.0 | 32.1 |
| Hopx | HOP homeobox | −2.0 | 1.1E-4 | 24.3 | 11.9 | 8.8 |
| Slc24a4 | solute carrier family 24 member 4 | −2.0 | 2.4E-3 | 44.3 | 21.8 | 20.3 |
| Stx3 | syntaxin 3 | 2.1 | 1.3E-4 | 1.9 | 4.1 | 4.7 |
| Neat1 | nuclear paraspeckle assembly transcript 1 | 2.2 | 1.0E-7 | 2.6 | 5.8 | 16.2 |
| Bmper | BMP-binding endothelial regulator | 2.4 | 2.9E-5 | 2.7 | 6.5 | 2.3 |
| Gstm1 | glutathione S-transferase, mu 1 | 2.4 | 2.7E-4 | 25.1 | 59.7 | 17.7 |
| Necab1 | N-terminal EF-hand calcium binding protein 1 | 2.4 | 9.8E-7 | 2.1 | 5.1 | 32.5 |
| 2310030G06Rik | RIKEN cDNA 2310030G06 gene | 2.9 | 3.4E-8 | 2.9 | 8.6 | 46.7 |
| Scel | sciellin | 3.5 | 4.3E-6 | 2.3 | 7.9 | 38.8 |
| Cyp26a1 | cytochrome P450, family 26, subfamily a, polypeptide 1 | 3.5 | 7.4E-6 | 3.4 | 12.0 | 4.1 |
| Serpinb6b | serine (or cysteine) peptidase inhibitor, clade B, member 6b | 3.8 | 1.6E-28 | 20.5 | 77.3 | 33.8 |
| Chrdl1 | chordin-like 1 | 4.2 | 7.7E-5 | 0.7 | 2.9 | 17.2 |
| Foxe3 | forkhead box E3 | 4.2 | 1.3E-3 | 3.8 | 16.3 | 4.0 |
| Ephx1 | epoxide hydrolase 1, microsomal [ | 4.7 | 1.3E-32 | 9.4 | 44.4 | 28.9 |
| Folr1 | folate receptor 1 (adult) | 4.8 | 1.2E-2 | 1.3 | 6.4 | 56.5 |
| Cdh1 | cadherin 1 | 5.0 | 1.9E-8 | 2.0 | 10.2 | 6.0 |
| Arsi | arylsulfatase i | 6.1 | 1.5E-2 | 0.8 | 5.1 | 9.5 |
| Cabp5 | calcium binding protein 5 | 6.2 | 1.9E-6 | 0.6 | 4.0 | 2.8 |
| Cdkn2b | cyclin dependent kinase inhibitor 2B | 6.4 | 5.8E-13 | 3.7 | 23.9 | 7.5 |
| Aldh3a1 | aldehyde dehydrogenase family 3, subfamily A1 | 9.2 | 3.0E-9 | 10.7 | 98.5 | 347.8 |
| Tinag | tubulointerstitial nephritis antigen | 11.6 | 1.3E-17 | 1.2 | 13.4 | 21.5 |