Table 1.
Baseline clinical and exercise test characteristics.
| Full cohort | High-grade PVCs during exercise | High-grade PVCs during recovery | |||||
|---|---|---|---|---|---|---|---|
| n=5,486 | No (n=5,385) | Yes (n=101) | p-value | No (n=5,353) | Yes (n=133) | p-value | |
| Clinical variables | |||||||
| Age (years) | 45.4 ± 10.8 | 45.1 ± 10.6 | 60.1 ± 11.8 | <.001 | 45.0 ± 10.5 | 61.4 ± 12.0 | <.001 |
| Women | 2,302 (42.0) | 2,252 (41.8) | 50 (49.5) | 0.121 | 2,232 (41.7) | 70 (52.6) | 0.012 |
| White race | 5,261 (95.9) | 5,162 (95.9) | 99 (98.0) | 0.779 | 5,128 (95.8) | 133 (100.0) | 0.212 |
| Diabetes | 173 (3.2) | 165 (3.3) | 8 (9.1) | 0.003 | 165 (3.4) | 8 (7.2) | 0.027 |
| Hypertension | 2,376 (43.3) | 2,317 (43.1) | 59 (58.4) | 0.002 | 2.293 (42.9) | 83 (62.4) | <.001 |
| Smoking | 3,541 (64.6) | 3,479 (64.6) | 62 (61.4) | 0.503 | 3,462 (64.7) | 79 (59.4) | 0.209 |
| Total cholesterol ≥ 240 mg/dL | 1,810 (33.0) | 1,768 (32.9) | 42 (41.6) | 0.067 | 1,761 (33.0) | 49 (36.8) | 0.352 |
| LDL-cholesterol ≥ 160 mg/dL | 1,878 (34.2) | 1,833 (34.2) | 45 (44.6) | 0.030 | 1,832 (34.4) | 46 (34.6) | 0.963 |
| HDL-cholesterol < 40 mg/dL | 1,440 (26.3) | 1,425 (26.6) | 15 (14.9) | 0.008 | 1,420 (26.7) | 20 (15.0) | 0.003 |
| Triglycerides ≥ 200 mg/dL | 1,155 (21.1) | 1,337 (24.8) | 24 (23.8) | 0.806 | 1,334 (24.9) | 27 (20.3) | 0.223 |
| Body mass index ≥ 30 kg/m2 | 763 (13.9) | 751 (14.0) | 12 (11.9) | 0.548 | 747 (14.0) | 16 (12.0) | 0.521 |
| Family history of premature coronary artery disease | 1,235 (22.5) | 1,213 (24.0) | 22 (25.0) | 0.827 | 1,206 (24.0) | 29 (23.0) | 0.791 |
| Exercise test variables | |||||||
| Exercise duration (minutes) | 8.5 ± 2.6 | 8.5 ± 2.6 | 5.4 ± 2.9 | <.001 | 8.6 ± 2.6 | 4.7 ± 2.7 | <.001 |
| Exercise duration ≥ median | 2,984 (54.4) | 2,967 (55.1) | 17 (16.8) | <.001 | 2,970 (55.5) | 14 (10.5) | <.001 |
| Heart rate recovery (bpm) | 55.0 ± 12.8 | 55.1 ± 12.7 | 51.1 ± 17.6 | 0.002 | 55.1 ± 12.6 | 52.2 ± 20.2 | 0.011 |
| Heart rate recovery ≥ median | 2,792 (50.9) | 2,754 (51.3) | 38 (37.6) | 0.007 | 2,736 (51.2) | 56 (42.4) | 0.046 |
| Target heart rate achieved | 3,953 (72.1) | 3,917 (72.7) | 36 (35.6) | <.001 | 3,913 (73.1) | 40 (30.1) | <.001 |
| ST depression ≥ 1 mm | 215 (3.9) | 202 (3.8) | 13 (13.0) | <.001 | 202 (3.8) | 13 (9.8) | <.001 |
Continuous variables (age, exercise duration, heart rate recovery) are presented as mean ± standard deviation, categorical variables (remaining variables) are presented as number (valid %).