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. Author manuscript; available in PMC: 2022 Dec 17.
Published in final edited form as: ACS Chem Biol. 2021 Dec 3;16(12):2834–2844. doi: 10.1021/acschembio.1c00746

Figure 9.

Figure 9.

Interspecies competition between S. oligofermentans and S. mutans. A. Individual colonies of S. mutans SMCC3 (UA159, ΔcomC, SpecR) (−), SMCOM3 (UA159, SpecR) (+), and wild type S. oligofermentans (O). B. Competition between SMCC3 (left) and S. oligofermentans (right). C. Competition between SMCOM3 (left) and S. oligofermentans (right). In both B and C, S. oligofermentans was exposed to the following conditions prior to co-inoculation with either S. mutans strain: 1. THY media; 2. THY media + 10 mM lactic acid; 3. THY media + 300 nM native CSP; 4. THY media + 2,500 nM CSP D1AK14A; 5. THY media + 10 mM lactic acid + 300 nM CSP; 6. THY media + 10 mM lactic acid + 2,500 nM CSP D1AK14A. Experiment was repeated three times in triplicate for a total of nine trials. See Materials and Methods for full experimental details.