. Author manuscript; available in PMC: 2023 May 1.

Published in final edited form as: Clin Gastroenterol Hepatol. 2021 Jul 2;20(5):e1083–e1120. doi: 10.1016/j.cgh.2021.06.044

Table 5.

Additive interaction between ABCG8 rs4245791 and body mass index in male and female participants

		BMI < 25 kg/m²	BMI ≥ 25 kg/m²	Interaction P-value
All participants (HPFS, NHS and NHS II)
rs4245791	Cases/Controls	791/3843	1615/4088
CC	OR^a (95% CI)	1.0^Ref	1.99 (1.88, 2.10)
rs4245791	Cases/Controls	758/3192	1621/3223
TT+TC	OR^a (95% CI)	1.16 (1.06, 1.26)	2.55 (2.41, 2.68)
Combined Association
Additive interaction: RERI for (95% Cl); H0^b: RERI = 0			0.39 (0.18, 0.61)	4.16×10⁻⁴
Additive interaction: SI (95% CI); H0^b: SI = 1			1.34 (1.16, 1.52)	1.63×10⁻³
Multiplicative interaction: IOR (95% CI); H0^b: IOR = 1			1.10 (0.96, 1.24)	1.71×10⁻¹
Among females (NHS and NHS II)
rs4245791	Cases/Controls	641/3235	1288/3233
CC	OR^a (95% CI)	1.0^Ref	2.10 (1.98, 2.22)
rs4245791	Cases/Controls	626/2678	1333/2509
TT+TC	OR^a (95% CI)	1.18 (1.07, 1.29)	2.82 (2.66, 2.97)
Combined Association
Additive interaction: RERI for (95% Cl); H0^b: RERI = 0			0.53 (0.27, 0.79)	6.05×10⁻⁵
Additive interaction: SI (95% CI); H0^b: SI = 1			1.41 (1.22, 1.60)	3.62×10⁻⁴
Multiplicative interaction: IOR (95% CI); H0^b: IOR = 1			1.13 (0.98, 1.29)	1.14×10⁻¹
Among males (HPFS)
rs4245791	Cases/Controls	150/608	327/855
CC	OR^a (95% CI)	1.0^Ref	1.57 (1.30, 1.83)
rs4245791	Cases/Controls	132/514	288/714
TT+TC	OR^a (95% CI)	1.05 (0.82, 1.27)	1.65 (1.33–1.98)
Combined Association
Additive interaction: RERI for (95% Cl); H0^b: RERI = 0			0.04 (−0.36, 0.44)	8.38×10⁻¹
Additive interaction: SI (95% CI); H0^b: SI = 1			1.07 (0.41, 1.72)	8.44×10⁻¹
Multiplicative interaction: IOR (95% CI); H0^b: IOR = 1			1.01 (0.69, 1.33)	9.55×10⁻¹

Odds ratios are unadjusted and conditional on matching factors.

H0 = the null hypotheses tests were for RERI = 0; Synergy Index = 1 and interaction odds ratio = 1