TABLE 1.

Association between allelic burden of somatic KRAS mutation and three phenotypes of BAVM severity

KRAS Mutation	No. of Patients	Age at Tissue Collection*		BAVM Size*		Age at First ICH†
		Coefficient (95% CI)	p Value	Coefficient (95% CI)	p Value	HR (95% CI)	p Value
G12D or G12V
Allelic burden %	56	0.7 (−2.9 to 4.3)	0.69	1.4 (−0.7 to 3.6)	0.18	0.87 (0.64–1.20)	0.40
Presence	56	1.3 (−8.9 to 11.4)	0.80	3.2 (−2.8 to 9.2)	0.29	0.77 (0.35–1.72)	0.53
G12D
Allelic burden %	57	2.4 (−2.6 to 7.3)	0.35	1.6 (−1.4 to 4.5)	0.30	0.95 (0.67–1.34)	0.76
Presence	57	1.6 (−9.5 to 12.7)	0.77	2.4 (−4.2 to 9.0)	0.47	0.90 (0.39–2.06)	0.80
G12V
Allelic burden %	65	−0.6 (−5.1 to 4.0)	0.80	0.9 (−1.6 to 3.4)	0.48	0.87 (0.56–1.35)	0.53
Presence	65	0.4 (−17.1 to 17.9)	0.97	3.0 (−6.6 to 12.5)	0.54	0.68 (0.16–2.96)	0.61

^*Results of linear regression models, adjusted for sex and prior ICH.

^†Results of Cox proportional hazards model, adjusted for sex and BAVM size. Patients without ICH at age of tissue collection were censored.