Comparison 4. Worst case scenario imputation ‐ symptomatic bacterial UTI.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Placebo comparison	6	352	Risk Ratio (M‐H, Random, 95% CI)	0.94 [0.63, 1.39]
1.1 Versus placebo	2	77	Risk Ratio (M‐H, Random, 95% CI)	3.71 [0.12, 112.47]
1.2 Versus placebo with recurrent UTI	4	275	Risk Ratio (M‐H, Random, 95% CI)	0.85 [0.60, 1.19]
2 Antibiotic comparison ‐ worst case probiotics	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
2.1 Versus antibiotics with recent UTI	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
3 Antibiotic comparison ‐ worst case antibiotics	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
3.1 Versus antibiotics with recent UTI	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]