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. Author manuscript; available in PMC: 2022 Dec 10.
Published in final edited form as: Sci Immunol. 2021 Dec 10;6(66):eabl5842. doi: 10.1126/sciimmunol.abl5842

Fig. 6. SARS-CoV-2 pseudovirus neutralization by naive and affinity-matured Abs.

Fig. 6.

(A) SARS-CoV-2 pseudovirus neutralization assay for 32 purified IgGs. Curves in color highlighted antibodies with neutralizing activity with donor and monovalent wild-type RBD affinity listed for this subset of antibodies. The neutralizing monoclonal antibody, B38, was used as a positive control. Dashed lines indicate IC50 values and data represent means ± SD of two technical replicates. (B) SARS-CoV-2 pseudovirus neutralization for select affinity matured progeny from the ab090 lineage with respective mutations relative to ab090 parent sequence, monovalent wild-type RBD affinity, and IC50 listed.