Fig. 4.

Influencing roles of TCs in HBE phenotype. Dynamic alterations of HBE cell proliferation (A–C), differentiation (D–F), and death (G–I) were monitored using the Cell-IQ alive system in mono-cultured (HBE) or co-cultured HBE cells (TCs/HBE) challenged with vehicle (V) or LPS at 1 μg/mL (A, D, and G), pretreated with PI3K p110δ inhibitor (CAL) at 0.01, 0.1, and 1 μM (B, E, and H), or pretreated with PI3Kα/δ/β inhibitor (LY) at 0.05, 0.5, or 5 μM (C, F, and I). * and ** stand for p values less than 0.05 and 0.01, as compared with HBE cells pretreated and challenged with vehicle, respectively