Table 2.
Comparison of patients eligible for DAPA-HF compared to ineligible patient according to exclusion criteria.
| Characteristic | Patients eligible for DAPA-HF (n = 352) | Patients not eligible due to NT-proBNP below threshold (n = 203) | Patient not eligible due to eGFR < 30 ml/min/m2 (n = 84) | ||
|---|---|---|---|---|---|
| p value | p value | ||||
| Age-yr | 79 (±10.0) | 70.9 (±12.3) | <0.001 | 84.0 (±8.0) | <.001 |
| Female sex-no. (%) | 119 (33.8) | 52 (23.6 | 0.02 | 33 (39.3) | 0.41 |
| Body mass index-kg/m2 | 26.4∗ (±4.9) | 28.7∗∗ (±5.0) | <0.001 | 27.3∗∗∗ (±4.9) | 0.13 |
| Heart rate- beats/min | 75.6 (±17.3) | 71.3 (±13.9) | 0.002 | 76.7 (±15.3) | 0.2 |
| Systolic blood pressure-mmHg | 124 (±18.2) | 125 (±16.8) | 0.2 | 128 (±19.5) | 0.6 |
| Left ventricle ejection fraction-% | 32.4 (±6.8) | 34.8 (±5.6) | <0.001 | 32.9 (±6.5) | 0.59 |
| Median NT-proBNP-Pg/ml (IQR) | 1943 (1138-3562) | 286 (164-476) | 3409.5 (1785-7073.75) | ||
| eGFR-ml/min/1.73 m2 | 54.4 (±15.0) | 65.5 (±17.8) | <0.001 | 21.5 (±5.9) | <0.001 |
| Rate of eGFR <60 ml/min/1.73 m2-no./total no. (%) | 239/352 (67.9) | 75/203 (36.9) | <0.001 | 84/84 (100) | |
| Hospitalization for heart failure-no. (%) | 182 (51.7) | 102 (47.8) | 0.42 | 39 (58.2) | 0.2 |
| Atrial fibrillation-no. (%) | 198 (56.3) | 65 (32.0) | <0.001 | 46 (54.8) | 0.9 |
| Diabetes mellitus-No. (%) | 74 (21.0) | 58 (28.6) | 0.06 | 35 (41.7) | <.001 |
| Hypertension-no. (%) | 222 (63.1) | 137 (67.4) | 0.34 | 69 (82.1) | .001 |
| Ischemic etiology-no. (%) | 163 (46.3) | 106 (48.2) | 0.52 | 41 (48.8) | 0.77 |
| Heart failure treatment | |||||
| ACE-inhibitor or ARB-no. (%) | 258 (73.3) | 151 (74.4) | 0.86 | 68 (81.0) | 0.19 |
| ARNI-no. (%) | 63 (17.9) | 45 (22.5) | 0.27 | 4 (4.8) | 0.005 |
| Beta blocker-no. (%) | 322 (91.5) | 192 (94.6) | 0.24 | 78 (92.9) | 0.8 |
| MRA-no. (%) | 213 (60.6) | 136 (67.0) | 0.15 | 35 (41.7) | 0.003 |
| Loop diuretics-no. (%) | 233 (66.2) | 96 (47.3) | <.001 | 76 (90.5) | <.001 |
| Digitalis-no. (%) | 56 (15.9) | 26 (12.8) | 0.39 | 13 (15.5) | 1 |
| ICD-no. (%) | 47 (13.4) | 52 (25.6) | <.001 | 6 (7.1) | 0.17 |
| CRT-no. (%) | 53 (15.1) | 37 (18.2) | 0.39 | 12 (14.3) | 0.9 |
Number in parentheses is ±1 standard deviation; eGFR: estimated glomerular filtration rate; NT-proBNP: N-terminal pro-B-type natriuretic peptide; ACE: angiotensin converting enzyme; ARB: angiotensin receptor blocker; ARNI: angiotensin receptor blocker and neprilysin inhibitor; MRA: mineral corticoid antagonist; ICD: implantable cardioverter-defibrillator; CRT: cardiac resynchronization therapy. p values are in relation to the eligible patients. ∗BMI available for 333/352 patients. ∗∗BMI available for 197/203 patients. ∗∗∗BMI available for 82/84 patients.