FIGURE 4.
Knockdown of LINC00460 decreased EGFR protein expression by increasing the expression of miR‐769‐5p in NSCLC, which influenced gefitinib resistance. 35 LINC00460 is involved in cell apoptosis by regulating the apoptosis proteins Bcl‐2, Bax, cleaved caspase‐2, and PI3K/AKT. 36 LINC00460 promoted cell migration and invasion through EMT‐related genes. LINC00460 affected cell proliferation via sponging miR‐539. 34 Knockdown of LINC00460 influenced lung adenocarcinoma growth by binding to miR‐302c‐5p and upregulating the expression of FOXA1. 22 LINC00460 also promoted EGFR‐TKI resistance in EGFR‐mutated lung adenocarcinoma by binding to miR‐149‐5p 37