FIGURE 8.
Knockdown of LINC00460 suppressed the expression of the cell proliferation‐related proteins cyclin D1 and CDK4 in HCC, inducing obvious cell cycle arrest. The expression of the cell migration‐related proteins MMP‐3 and MMP‐9 was also greatly suppressed after LINC00460 knockdown. 43 Knockdown of LINC00460 affected cell apoptosis by elevating the expression of Bax and reducing the expression of Bcl‐2. Knockdown of LINC00460 suppressed AGR2 expression by targeting miR‐342‐3p to affect cell proliferation, migration, and apoptosis of HCC. 44 LINC00460 knockdown inhibited PAK1 levels by sponging miR‐485‐5p to affect cell proliferation, migration, and apoptosis 24