FIGURE 7.

Longitudinal ctDNA analysis to monitor the response of a patient with lung cancer (JFJ) to chemotherapy. (a) Flow chart of the clinical course of patient JFJ, starting from the time of diagnosis and throughout the treatment. The light‐blue bars represent the treatment time frame, whereas the red dots indicate the time points of blood collection. Radiographic images were acquired at days 0, 45, and 84. PR in red indicates the clinical outcome of chemotherapy in the patient at different time points. (b) Mutation allele frequency of patient JFJ during chemotherapy. The different color curves correspond to different time points of blood collection. The abscissa is the variant allele frequency. The ordinate Fn (x) represents the cumulative percentage. (c) Frequency of tumor mutations compared with the normal control at different time points. VMF is variant mutation frequency