Table 1.
The coumarin derivatives with anti-CHIKV activity.
Compound | Chemical structure | CC50a (μM) | EC50b (μM) | SI |
---|---|---|---|---|
29 | ![]() |
178 | 19.1 | 9.3 |
30 | ![]() |
117 | 10.2 | 11.5 |
31 | ![]() |
144 | 17.2 | 8.8 |
32 | ![]() |
107 | 19.0 | 5.6 |
33 | ![]() |
75.2 | 13.0 | 5.8 |
34 | ![]() |
>212 | 9.9 | >21.7 |
35 | ![]() |
96.5 | 10.3 | 9.37 |
36 | ![]() |
>227 | 13.9 | >16.3 |
37 | ![]() |
3150.0 | 10.7 | 295.2 |
38 | ![]() |
549.8 | 0.5 | 1021.0 |
CC50: the half cytotoxic concentration.
EC50: the median effective concentration.