. 2021 Feb 27;9(1):201–215. doi: 10.1016/j.gendis.2021.02.008

Table 3.

Key DEGs significantly changed involved in lipid metabolic process in the liver of each mouse model.

Metabolic process	Changes of top genes in each group
	DEX induced NAFLD			HSHF induced NAFLD			db/db
	Gene name	Log₂ (Fold Change)	FDR	Gene name	Log₂ (Fold Change)	FDR	Gene name	Log₂ (Fold Change)	FDR
Lipid	Srebf1	−2.28955	0.00116535	Apoa4	3.95879	0.00256724	Pnpla3	4.94022	0.00057796
	Elovl2	−1.01537	0.0011653	Scd1	2.75418	0.00256724	Scd1	3.04407	0.0005776
	Acnat1	−1.01528	0.019002	Srebf1	2.15722	0.00256724	Elovl6	3.11782	0.00057796
	Sqle	−1.97855	0.00116535	Elovl5	1.89249	0.00256724	Elovl5	2.46632	0.00057796
	Plin5	2.37117	0.00116535	Lpl	1.94893	0.00256724	Cd36	4.45396	0.0005779
	Acly	−1.65391	0.00116535	Smpd3	2.88631	0.0203045	Pparg	2.28283	0.00057796
	Insig1	−2.18166	0.00116535	Cd36	1.79329	0.00256724	Ppargc1a	2.11752	0.03424480
	Insig2	1.96634	0.0011653	Pparg	1.65057	0.00256724	Acly	1.45867	0.00057796
	Fasn	−1.68574	0.00298341	Apoc2	1.41882	0.0104423	Acnat2	4.83398	0.0005779
	Apoa4	3.01287	0.00116535	Cyp17a1	1.42665	0.00256724	Insig2	2.36451	0.00057796
	Fabp1	−1.0047	0.00116535				Fasn	2.07406	0.000577962
	Acot1	1.32154	0.0170247				Apoa4	1.6458	0.00057796
	Lpin1	1.99705	0.00116535				Scd2	1.66453	0.00057796
	Dhcr7	−1.36218	0.00116535				Pck2	−1.86523	0.00057796
	Hmgcr	−1.51934	0.00116535				Hacl1	1.3138	0.00155599
	Pcsk9	−2.11944	0.00116535				Pdk4	3.26674	0.00057796
	Acsl3	−2.48382	0.0011653				Gpam	2.4615	0.00057796
	Acox1	−1.09071	0.0052477				Pdk1	1.47899	0.00057796
	Fads2	−1.20849	0.00116535				Gpat2	−1.23393	0.02466420
	Fads3	−1.71553	0.00116535				Fabp5	−1.53929	0.000577962
	Soat2	−1.00581	0.00593422				Fabp4	1.10654	0.00057796
							Acot1	1.70572	0.00057796
							Lpin1	−2.43886	0.00057796
							Elovl2	−1.84094	0.00057796
							Acsl5	1.03864	0.00057796