Table 4.
Common key DEGs in each moue model of NAFLD in comparison with each other.
| Types of DEGs | Gene Names |
|---|---|
| HSHF vs. db/db | |
| DEGs upregulated in both HSHF induced NAFLD and db/db mice (n = 91) | Ly6d, Cyp2a22, Themis, Ttc39a, Acnat2, Acss3, Hamp2, Cd36, Rcan2, Lcn2, Cidec, Cyp17a1, Extl1, Osbpl3, Robo1, Tmem28, Smpd3, Eda, Fam131c, Scd1, Tubb2a, Ubd, Gal3st1, Slc35f2, Elovl5, Tceal8, Tmem98, Abcb1a, Dntt, Pparg, Saa2, 2010003K11Rik, Sulf2, Mest, Acot11, Vnn1, Fam83f, S100a10, Lgalsl, Chchd6, Limk1, Mmd2, Thrsp, Gdf15, Anxa2, Aqp8, Cyp2a4, Them6, Tenm3, Slc17a4, Scd2, Apoa4, Rxrg, Fam124a, Mms22l, Bhlhb9, Acyp2, Acaa1b, Tnfrsf19, Mup19, Ifi27l2b, Saa1, Enc1, Myo1d, Ptp4a3, Anxa5, Copz2, Mgst3, S100a11, Sorbs1, Cldn2, Synj2, Lgals1, Adam11, Gsta1,Abcd1, Ppm1h, Mcm5, Wfdc2, Gale, Srxn1, Ermp1, Abcd2, Samd9l, Fabp4, Serpina7, Unc119, Pgd, Tnip1, Maged2, Gas6 |
| DEGs downregulated in both HSHF induced NAFLD and db/db mice (n = 30) | Slc13a2, Cyp1a2, Gadd45g, Ppp1r3g, Mup13, BC089597, Igfbp1, Fam222a, Cyp51, Sqle, Mup15, C8b, Hsd17b6, Mup14, Idi1, Lama3, Cxcl13, Lifr, Susd4, E130012A19Rik, Cabyr, Mup11, Cyp7b1, Mup12, Cadm4, Selenbp2, Gpr110, Mup7, Enho, Serpina1e |
| DEGs upregulated in HSHF induced NAFLD but downregulated in db/db mice (n = 15) | Pld4, Lsp1, H2-Eb1, Dsg1c, Smoc2, Nrep, Arhgdib, Tnfsf12, Selplg, Coro1a, Ccl6, H2-Ab1, H2-Aa, H2-DMb1, Tlr12 |
| DEGs upregulated in db/db but downregulated in HSHF induced NAFLD mice (n = 8) | Acot6, Raet1d, Raet1e, Cyp2c40, Etnppl, Dct, G6pc, Cyp26a1 |
| HSHF vs. DEX | |
| DEGs upregulated in both HSHF induced NAFLD and DEX-treated mice (n = 9) | Apoa4, Lcn2, Saa1, Gramd1b, Gdf15, Thrsp, Lyve1, Rgs16, Plin3 |
| DEGs downregulated in both HSHF induced NAFLD and DEX-treated mice (n = 15) | Cyp51, Fbf1, Sqle, Sik1, Cabyr, Hsd17b6, Nsdhl, Sc4mol, Ccbl2, Lifr, Ugt2b37, Idi1, Ugt2b38, Cyp2c54, BC089597 |
| DEGs upregulated in HSHF induced NAFLD but downregulated in DEX-treated mice (n = 24) | Aqp8, Srebf1, Serpina7, H2-Ab1, Hamp2, H2-Aa, Cd74, Tmem106a, Nrep, Mpeg1, Krt18, Cldn2, Abcg5, Paqr7, Trp53i11, Abcd1, Acaa1b, Tenm3, Ddx58, Fads2, Abcg8, Sorbs1, Klhdc7a, Cybb |
| DEGs upregulated in DEX-treated but downregulated in HSHF induced NAFLD mice (n = 5) | Tat, Arrdc2, Igfbp1, Gadd45g, Scara5 |
| DEX vs. db/db | |
| DEGs upregulated in both DEX-treated and db/db mice (n = 24) | Acacb, Acot1, Treh, Mt2, Obp2a, Agpat9, Cyp2b10, Lcn2, Mt1, Ppp1r3c, Gdf15, Apoa4, Saa1 Slc45a3, Cyp4a14, Prob1, Insig2, Chd1l, Mfsd2a, Fmo5, Thrsp, Gldc, 1810011O10Rik, Bhmt |
| DEGs downregulated in both DEX-treated and db/db mice (n = 40) | Zfp707, Marco, Ccnd1, Dna2, Irgm2, Rapgef4, Cyp51, Lifr, Dbp, Ttc39c, Apol9b, H2-Aa, Mup3, Irf6, Elovl2, Mug2, BC089597, Fbxo21, Cdh1, Slco1a1, Hsd17b6, Rnase4, Sel1l3, Adh6-ps1, Ces1c, Phlda1, Keg1, Ces1b, Nrp1, Nudt7, Sqle, H2-Ab1, Idi1, Mapk15, Sort1, Cabyr, Aox3, Marveld2, Cyp2u1, Nrep |
| DEGs upregulated in DEX-treated but downregulated in db/db mice (n = 6) | Porcn, Serpine2, Lipin1, Gadd45g, Igfbp1, AA986860 |
| DEGs downregulated in DEX-treated but upregulated in db/db mice (n = 42) | Ccng1, Hnmt, Gtdc1, 5033411D12Rik, Caln1, Tenm3, Gm13152, Acad10, Hacl1, Abcd1, Rtn4, Hamp2, Cd59a, Btbd7, Adra1b, Pls3, Entpd5, Tlr5, Rwdd3, E2f3, Sorbs1, Pla2g15, Fasn, Nat8, Slc25a10, Aldh1a1, Bche, Paqr9, Ebpl, Rdh16, Prkdc, Slc16a7, Aqp8, Nfe2l2, Acly, Lrit1, Cyp2c38, Acaa1b, Serpina7, Mme, Prlr, Cldn2 |
| DEX vs. HSHF vs. db/db | |
| DEGs upregulated in all three groups (n = 5) | Apoa4, Lcn2, Saa1, Gdf15, Thrsp |
| DEGs downregulated in all three groups (n = 7) | Cyp51, Sqle, Cabyr, Hsd17b6, Lifr, Idi1, BC089597 |
| DEGs upregulated in DEX-treated but downregulated in both db/db and HSHF induced NAFLD mice (n = 2) | Gadd45g, Igfbp1 |
| DEGs downregulated in DEX-treated but upregulated in both db/db and HSHF induced NAFLD mice (n = 8) | Tenm3, Abcd1, Hamp2, Sorbs1, Aqp8, Acaa1b, Serpina7, Cldn2 |
| DEGs upregulated in HSHF-induced NAFLD but upregulated in both db/db and DEX-treated mice (n = 3) | H2-Ab1, H2-Aa, Nrep |