Table 5.
Comparison of over-presented functional enrichment analysis performed on the shared pathways between three mouse models of NAFLD.
| Pathways |
Different Models |
|||||
|---|---|---|---|---|---|---|
| GO and KEGG pathway terms | DEX |
HSHF |
db/db |
|||
| Regulation | BH.p value | Regulation | BH.p value | Regulation | BH.p value | |
| GO:0008202 Steroid Metabolic Process | down | 1.10783E-11 | down | 3.9539E-05 | up | 0.000592725 |
| GO:0010876 Lipid Localization | down | 1.20163E-05 | up | 7.07082E-05 | up | 5.54001E-05 |
| GO:0006805 Xenobiotic Metabolic Process | down | 6.87516E-07 | down | 0.015039461 | up | 4.63612E-09 |
| GO:0062012 Regulation Of Small Molecule Metabolic Process | down | 1.97349E-06 | up | 1.42514E-05 | up | 0.005334651 |
| GO:0044282 Small Molecule Catabolic Process | up | 0.003188734 | up | 0.006204059 | up | 4.63612E-09 |
| GO:0035634 Response To Stilbenoid | down | 0.00084057 | up | 1.76742E-06 | up | 2.68169E-06 |
| GO:0042737 Drug Catabolic Process | up | 0.003188734 | down | 0.02905059 | up | 9.41721E-08 |
| GO:0062013 Positive Regulation Of Small Molecule Metabolic Process | down | 0.006111985 | up | 4.26301E-06 | up | 0.003422671 |
| GO:1901615 Organic Hydroxy Compound Metabolic Process | down | 1.14533E-05 | down | 0.002631838 | up | 1.68246E-06 |
| Mmu00980 Metabolism Of Xenobiotics By Cytochrome P450 | down | 0.00366925 | down | 0.04096318 | up | 0.007078388 |
| mmu02010 ABC Transporters | down | 0.005205567 | up | 0.00718615 | up | 0.013547692 |
| mmu03320 PPAR signaling pathway | / | / | up | 4.45039E-05 | up | 1.96799E-08 |
| mmu01212 Fatty acid metabolism | down | 0.020176687 | / | / | up | 0.000577213 |
| mmu01040 Biosynthesis of unsaturated fatty acids | / | / | up | 0.001703037 | up | 3.42971E-06 |
| mmu00830 Retinol metabolism | down | 1.44555E-11 | down | 9.7534E-08 | up | 2.35428E-10 |
| mmu00591 Linoleic acid metabolism | / | / | down | 0.019186006 | up | 0.049841292 |
| mmu00100 Steroid biosynthesis | down | 0.000107417 | down | 2.97813E-05 | / | / |
| GO:1990845 Adaptive thermogenesis | / | / | up | 9.50564E-05 | up | 1.467E-05 |
| GO:1901568 Fatty acid derivative metabolic process | down | 0.000479109 | / | / | up | 9.22256E-06 |
| GO:0120162 Positive regulation of cold-induced thermogenesis | / | / | up | 0.001272215 | up | 0.003804817 |
| GO:0009410 Response to xenobiotic stimulus | down | 0.000143497 | / | / | up | 9.50984E-07 |
| GO:0006869 Lipid transport | down | 1.37567E-05 | / | / | up | 0.000688304 |
| GO:0006790 Sulfur compound metabolic process | down | 5.15667E-05 | / | / | up | 6.22691E-15 |
| GO:0006732 Coenzyme metabolic process | down | 9.23777E-05 | / | / | up | 4.63612E-09 |
| GO:0001659 Temperature homeostasis | / | / | up | 7.54435E-05 | up | 0.003811025 |
GO, Gene Ontology; NAFLD, nonalcoholic fatty liver disease; HSHF, high sucrose high fat; BH, Benjamini and Hochberg.