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. 2021 Dec 20;12:799124. doi: 10.3389/fimmu.2021.799124

Figure 2.

Figure 2

Phenotype of platelet-CD4 + T cell aggregates in HCs, TNs, IRs, and INRs. The phenotypic characteristics of platelet-CD4 + T cell aggregates were analyzed, including platelet activation, CD45RO expression, HIV-1 co-receptors, immune checkpoint receptors, activation markers, and pyroptosis/apoptosis markers, as well as anti-apoptotic proteins from HCs, TNs, IRs, and INRs. Platelet-CD4+ T cell aggregates and platelet-free CD4+ T cells were compared with regards to their expression of CD62P (A) [HCs (n=19), TNs (n=20), IRs (n=16), and INRs (n=11)], CD45RO (B) [HCs (n=11), TNs (n=18), IRs (n=14), and INRs (n=11)], CCR5 (C) [HCs (n=17), TNs (n=18), IRs (n=21), and INRs (n=12)], CXCR4 (D) [HCs (n=13), TNs (n=13), IRs (n=17), and INRs (n=12)], CD38/HLA-DR (E) [HCs (n=11), TNs (n=13), IRs (n=17), and INRs (n=11)], PD-1 (F) [HCs (n=8), TNs (n=17), IRs (n=17), and INRs (n=11)], caspase-1 (G) [HCs (n=16), TNs (n=15), IRs (n=15), and INRs (n=10)], caspase-3 (H) [HCs (n=16), TNs (n=15), IRs (n=16), and INRs (n=10)], and Bcl-2 (I) [HCs (n=10), TNs (n=16), IRs (n=16) and INRs (n=11)]. *P < 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001.