Table 1.
Baseline characteristics of the enrolled participants.
| Parameter | HCs (n = 19) | TNs (n = 28) | IRs (n = 21) | INRs (n = 12) | ||
|---|---|---|---|---|---|---|
| CD4 ≤ 200 | 200<CD4 ≤ 350 | CD4>350 | ||||
| Age (year) | 33 (23-49) | 39 (33-62) | 29 (19-59) | 43.5 (20-56) | 37 (23-50) | 35.5 (30-42) |
| Gender (M/F) | 11/8 | 8/1 | 13/0 | 6/0 | 20/1 | 12/0 |
| CD4+T cell (cells/μL) | 687 (427-1013) | 87 (2-195) | 285 (236-334) | 422.5 (373-617) | 621 (373-1080) | 148 (69-346) |
| CD8+T cell (cells/μL) | 599 (272-1744) | 995 (449-1798) | 1069 (614-2618) | 844 (611-2284) | 718 (355-1612) | 668 (382-2306) |
| Viral Load (log10 copies/mL) |
NA | 4.65 (4.12-5.36) | 4.72 (3.23-5.44) | 4.09 (3.13-6.10) | <LDL | <LDL |
| CD4/CD8 Ratio | 1.24 (0.52-1.91) | 0.11 (0.002-0.2) | 0.28 (0.1-0.43) | 0.50 (0.25-0.72) | 0.73 (0.33-1.79) | 0.23 (0.09-0.51) |
Data are expressed as median (range). HC, healthy controls; TNs, treatment-naïve HIV-1-infected individuals; IRs, immunologic responders receiving successful ART; INRs, immune non-responders to ART; n, number of individuals per group; NA, not applicable; M, male; F, female; LDL, lower detection limit. TNs are divided into three subgroups according to blood CD4+ T cell count.