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. Author manuscript; available in PMC: 2022 Jan 3.
Published in final edited form as: Neuron. 2019 Oct 23;104(6):1153–1167.e4. doi: 10.1016/j.neuron.2019.09.023

Figure 1. Optogenetic fMRI reveals robust but divergent responses to thalamocortical stimulation in VLO at 10 and 40 Hz.

Figure 1.

(A) Experimental design for virus injection and thalamocortical stimulation. (B) Schematic of 23 coronal slices acquired in ofMRI experiments. (C) Design matrix for the block-design stimulation paradigm. (D,E) Group-level activation maps during thalamocortical stimulation at 10 (D) and 40 (E) Hz (N=11 animals; p < 0.05, FWE-corrected). In these and all other activation maps, white triangles indicate site of stimulation; warm colors indicate positive t-scores; cool colors indicate negative t-scores; image numbers correspond to slices shown in panel B. (F,G) Single-cycle fMRI time series from segmented areas of ipsilateral (F) and contralateral (G) cortex. Horizontal blue lines indicate the stimulation period. Error bars represent mean ± s.e.m. across animals (N=11). See also Figures S1–S4.