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. 2021 Dec 20;8:814402. doi: 10.3389/fcvm.2021.814402

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Copyright © 2021 Liu, Dong, Dong, Song, Zhang, Liang, Liu, Sun, Li, Zhang, Chen, Miao and Zhong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of circRNA-miRNA-mRNA network in aortic vascular tissues of rats. The red color and blue color represent upregulated and downregulated significant DE circRNAs, respectively. Green color represents miRNAs, yellow color represents mRNAs. Red bold lines represent three promising circRNA-miRNA-mRNA regulatory axes were selected in hypertensive rat aorta, including rno_circRNA_0005818/miR-615/NOTCH1, rno_circRNA_0009197/miR-509-5p/FOXO3 and rno_circRNA_0005818/miR-10b-5p/STAT3, respectively. circRNAs, circular RNAs; miRNA, microRNA; mRNA, messenger RNAs; DE, differentially expressed.