Table 5.
Signals of ADRs.
| Drug | ADR | No. | ROR | 95% CI Lower limit | PRR | 95% CI Lower limit | χ2 |
|---|---|---|---|---|---|---|---|
| Vincristine | Alopecia | 4 | 63.39 | 10.64 | 48.71 | 10.90 | 327253.85 |
| Asparaginase | Cyanosis a | 3 | 21.64 | 2.21 | 20.51 | 2.22 | 114461.47 |
| Pegaspargase | Itch a | 3 | 17.29 | 2.79 | 15.97 | 2.82 | 94729.67 |
| Methotrexate | Mucositis oral | 7 | 63.50 | 7.63 | 54.57 | 7.69 | 42646.14 |
| Asparaginase | Dyspnea | 6 | 15.22 | 3.69 | 13.67 | 3.73 | 11950.02 |
| Methotrexate | Hepatic failure | 4 | 6.70 | 1.74 | 6.24 | 1.75 | 11208.07 |
| Pegaspargase | Fibrinogen decreased | 4 | 5.85 | 1.67 | 5.32 | 1.69 | 8295.83 |
| Asparaginase | Fibrinogen decreased | 8 | 15.83 | 4.59 | 13.67 | 4.65 | 5071.55 |
| Cyclophosphamide | Reaction gastrointestinal | 7 | 9.08 | 3.31 | 7.20 | 3.41 | 2756.44 |
| Fludarabine | Myelosuppression | 3 | 17.02 | 1.74 | 5.00 | 3.74 | 1256.66 |
| Cisplatin | Vomiting | 6 | 8.31 | 2.57 | 4.66 | 3.00 | 686.61 |
| Etoposide | Rash a | 7 | 3.14 | 1.22 | 2.46 | 1.29 | 236.91 |
| Pegaspargase | Rash | 13 | 4.00 | 1.91 | 2.95 | 2.01 | 73.08 |
| Asparaginase | Rash | 18 | 3.87 | 2.02 | 2.93 | 2.12 | 25.59 |
a
Off-label ADR.