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. 2021 Dec 20;12:809208. doi: 10.3389/fimmu.2021.809208

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Copyright © 2021 Yang, Wu, Sun, Fang, Liu, Ji, Park, Qin, Yang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of SDE immune checkpoint gene and function implication in Ly6C MC subset in CT and ApoE ^-/- mice. (A) Expression profile of SDE immune checkpoint gene. Sixteen pairs of SDE co-stimulatory and 11 pairs of SDE co-inhibitory molecules are identified in four comparison groups. (B) SDE immune checkpoint gene functional implication in Ly6C MC subsets in ApoE ^-/- mice. ↑ refers to induce expression by ApoE ^-/-. ↓ refers to reduce expression by ApoE ^-/-, ± refers to no changes in ApoE ^-/-. (C) Model of SDE immune checkpoint gene and functional implication. Red letter highlighted the representative up-regulated gene. Blue letter highlighted down-regulated genes. Bold letter emphasized pro-atherogenic function. NA, Not applicable.