Figure 7.

APC potential is higher in Ly6C^low MC and elevated by ApoE ^-/- in Ly6C^low and Ly6C^low MC. (A) Expression pattern of SDE MHCII gene in Ly6C MC in CT and ApoE ^-/- mice. Heatmap color density indicates the average expression level of a given gene normalized by z-score. Red/blue rainbow background in the table represents the gradient of increased/reduced fold change (log₂FC>1, log₂FC<-1). (B) SDE MHCII gene orthologous to human HLA, location and function implication. Identified mouse SDE MHCII gene orthologous to human corresponding HLA gene, gene locus and function implication were search from large database (https://www.alliancegenome.org). (C) Model of MHCII complex and APC feature and functional implication in Ly6C MC subset. Model outlines that eight SDE MHCII molecules were upregulated in Ly6C^low MC in both mice and that ApoE ^-/- further induced MHCII gene expression. Cloud-like cell shape indicade APC potential. MHCII, major histocompatibility complex class II; Ag, antigen; IFN-γ, Interferon gamma; CLIP, class II-associated invariant chain peptide; NOS, Nitrous Oxide Systems.