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. 2021 Dec 20;13:745046. doi: 10.3389/fnagi.2021.745046

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Copyright © 2021 Majerníková, den Dunnen and Dolga.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential expression of ferroptosis related genes in AD mice model compared to WT mice. Heatmap representing the difference in expression of ferroptosis-related genes between 18 months old WT (orange) and AD mice (light blue) (A). The heatmap depicts gene expression from low/white to high/dark blue. Each point indicates one spatial transcriptomic spot defining one tissue domain on the slide. Glutathione peroxidase 4 (Gpx4) is upregulated with pathology (B), while glutathione synthase (Gss) (C) and acyl-CoA synthetase long-chain family member (Acsl4) (D) are downregulated with the pathology. This data is freely accessible online, Alzmap (Chen et al., 2020).