TABLE 4.

Characteristics of included articles assessing therapeutic options to prevent ferroptosis in AD stratified by mechanisms involved in ferroptosis.

Author (year)	AD model			Compound	Administration			Positive effect
	Species	Sex	Age (year)		Form	Time (months)	Amount	Aβ	pTau	Inflamation	Cognition
Iron homeostasis
Adlard et al., 2011	Tg2576 mice	♀	1.2	PBT2	o	0.4	30 mg/kg/d	NR	NR	NR	Y
Adlard et al., 2008	Tg2576 and APP/PS1 mice	♂, ♀	1.5–1.8	PBT2	o	0.4	30 mg/kg/d	Y	Y	NR	Y
Cherny et al., 2001	Tg2576 mice	♂, ♀	1.75	PBT1	o	2	2 mg/kg/d	Y	NR	NR	Y
Crouch et al., 2011	Aβ-induced SH−SY5Y cells	NA	NA	PBT2	NA	1 h	10–20 μM	Y	NR	NR	NA
Fine et al., 2012	TgP301L mice	NR	0.7	DFO	in	5	3 × 2.4 mg/w	Y	NR	Y	Y
Grossi et al., 2009	TgCRND8 mice	♂, ♀	0.3	PBT1	o	1.2	30 mg/kg/d	Y	NR	Y	Y
Guo et al., 2015	APP/PS1 mice	♂	0.5	DFO	in	3	200 mg/kg/2d	Y	NR	NR	NR
Guo et al., 2013	APP/PS1 mice	♂	0.5	DFO	in	3	200 mg/kg/2d	NR	Y	NR	NR
McLachlan et al., 1993	AD patients	♂, ♀	80	DFO	im	24	300 mg/d/5d/w	NR	NR	NR	Y
McLachlan et al., 1991	AD patients	♂, ♀	80	DFO	im	24	300 mg/d/5d/w	NR	NR	NR	Y
Ritchie et al., 2003	AD patients	NR	NR	PBT1	o	8.3	300–750mg/d	Y	NR	NR	Y
Glutathione metabilism
Dumont et al., 2009	Tg19959 mice	NR	0.1	CDDO-MA	o	3	800 mg/kg chow	Y	NR	Y	Y
Fragoulis et al., 2017	APP/PS1 mice	NR	0.5	Methysticin	o	6	6 mg/kg/w	N	NR	Y	Y
Kanninen et al., 2009	APP/PS1 mice	♂	0.75	LV-Nrf2	icv	NA	2-μL	Y	NR	Y	Y
Kerr et al., 2017	ArcAβ42 flies	♂, ♀	7d	LiCl	o	NA	100 mM	Y	NR	NR	NR
Kim et al., 2013	Aβ-induced ICR mice	♂	0.4	SFN	ip	4d	30mg/kg/d	N	NR	NR	Y
Lipton et al., 2016	hAPP-J20 and 3xTg mice	NR	0.3–0.5	CA	in	3	2 × 10mg/kg/w	Y	Y	Y	Y
Nassireslami et al., 2016	Aβ-induced wistar rats	♂	NR	SA	icv	NA	5–100 nM	Y	NR	Y	Y
Wang et al., 2016	APP/PS1 mice	♂	0.3	Dl-NBP	o	5	60 mg/kg/d	Y	NR	NR	Y
Oxidative stress and lipid peroxidation
Adair et al., 2001	AD patients	NR	NR	NAC	NR	6	50 mg/kg/day	NR	NR	NR	N
Ates et al., 2020	APPswe/PS1ΔE9 mice	♂	0.75	CMS121	o	3	34 mg/kg/d	NR	NR	Y	Y
	Aβ-induced MC65 cells	NA	NA	CMS121	NA	NR	NR	Y	NR	NR	NA
Cong et al., 2019	Aβ-induced SH−SY5Y cells	NA	NA	Chal.14a-c	NA	NA	25μM	Y	NR	NR	NA
Fu et al., 2006	Aβ-induced kunming mice	♂	0.3	NAC	ip	7d	50–200 mg/kg/d	Y	NR	NR	Y
McCaddon and Davies, 2005	AD patients	♂	65	NAC	o	NR	600 mg/d	NR	NR	NR	Y
Remington et al., 2009	AD patients	NR	NR	NAC	o	6–9	600 mg/d	NR	NR	NR	Y
Zhang et al., 2018	P301S mice	♀	0.4	LA	ip	2.3	3–10 mg/kg/d/5d/w	NR	Y	Y	Y
Zhang et al., 2017	3xTg mice	♂, ♀	0.7	Se-Met	o	3	6 μg/ml	NR	Y	NR	Y
Sripetchwandee et al., 2016	Wistar rats on HI diet	♂	0.2	DFO	ip	2	75-mg/kg/d	Y	Y	NR	NR
				NAC		2	100 mg/kg/d

Articles are sorted in alphabetical order and from more to less recent.

(hAPP)-J20; mouse expressing the human amyloid precursor protein, 3xTg AD; mutant mouse with PS1M146V gene, APP/PS1; [B6C3-Tg(APPswe,PSEN1 dE9)85Dbo/J], APPswe/PS1ΔE9; transgenic mice express a mouse/human chimeric APPswe and a mutant human presinilin 1 (PS1ΔE9), ArcAβ42; Aβ42-expressing drosophila, CA; carnosic acid, Chal. 14a-c; Chalcones 14a, DFO, deferoxamine, FASN; fatty acid synthase, HI; high iron, LA; α-Lipoic acid, LV-Nrf2; human Nrf2 lentiviral vector, LiCl; lithium, N; no, NA; not applicable, NR; not reported, P301S; [B6C3-Tg (Prnp-MAPT*P301S) PS19 Vle/J], PBT1; clioquinol, SA; sodium arsenite, SFN; sulforaphane, SH-SY5Y; human neuroblastoma cells, Se-Met; selenomethionine, Tg2576; mouse line encoding human APP695 with Lys670-Asn and Met671-Leu mutations, Y; yes, d; day, icv; intracerebroventricular, im; intramuscular, in; intranasal, ip; intraperitoneal, o; oral, w; week, y; year.