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. 2021 Dec 29;14:3909–3918. doi: 10.2147/JPR.S344568

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© 2021 Vallejo et al.

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Evoked compound action potential (ECAP) sensing in response to each pulse from Program #1 allows for closed-loop control of both Program #1 and #2, as governed by the feedback loop in (A). Multiple “therapy frames” (stimulation patterns with a common color) are shown in (B). The ECAP elicited from the pulse in Program #1 for one therapy frame informs the characteristics of the subsequent frame; this framework enables frame-by-frame volume of tissue activation control with multiple waveform patterns.