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. 2021 Dec 20;12:755825. doi: 10.3389/fphar.2021.755825

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Copyright © 2021 Belo, Cordeiro, Oliveira, Braga, da Silva, Costa, Martins, Jan, Le Loir, Gala-García, Ferreira, Azevedo and do Carmo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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L. lactis-SlpB mitigates histological signs of DSS-colitis. Model images of micrographs for analysis of goblet cells in colon tissue (A) and the result of goblet cell quantification by field (B) and depth of colon intestinal crypts (C) are shown. The slides were stained in Periodic Acid-Schiff (PAS), goblet cells have intense purple-pink tones, and analyzed under ×40 magnification. The data represent the mean ± SD of 12 mice per group. One-way ANOVA and Tukey’s post-hoc tests were used for multiple comparisons. Asterisks represent statistically significant differences as follows: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.