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. 2021 Dec 20;12:755825. doi: 10.3389/fphar.2021.755825

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Copyright © 2021 Belo, Cordeiro, Oliveira, Braga, da Silva, Costa, Martins, Jan, Le Loir, Gala-García, Ferreira, Azevedo and do Carmo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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L. lactis-SlpB increases the expression of genes involved in epithelial barrier protection. Quantification of the expression of the genes Mucin 2 (muc2) (A), Zonula Occludes 1 (zo-1) (B), Zonula Occludes 2 (zo-2) (C), Claudin-1 (cln-1) (D), Claudin-5 (cln-5) (E), and Occludin (ocln) (F), in the mice colon, is shown. One-way ANOVA and Tukey’s post-hoc tests were used for multiple comparisons. The data represent the mean ± SD of six mice per group. Asterisks represent statistically significant differences as follows: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.