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Small-molecule inducers or activators targeting Sesns may be used in diagnosis, treatment, and prevention of human diseases. Sesn, sestrin; CAD, coronary heart disease; OSA, obstructive sleep apnea; aGvHD, acute graft-versus host disease; CRC, colorectal cancer; CHF, chronic heart failure; AD, Alzheimer's disease; HCC, hepatocellular carcinoma; NSCLC, non-small-cell lung cancer; PD, Parkinson’s disease; COPD, chronic obstructive pulmonary disease; SCC, squamous cell carcinoma
