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. 2021 Dec 20;12:759040. doi: 10.3389/fphar.2021.759040

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Copyright © 2021 Liu, Wang, Li, Hu, Xu, Wu, Bai, Ping, Lan and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of methyl gallate on PO-induced HN. (A–C) Cytokines such as IL-6 (A), IL-1β (B) and TNF-α (C) in kidney were detected by ELISA kits. (D) The activity of XOD in liver was detected by referring to the kit instructions. (E,F) HE-staining (E) or Masson staining (F) of kidney from mice in different groups. Scale bar, 100 μm. a: control; b: vehicle; c: allopurinol (5 mg/kg); d: MG (20 mg/kg); e: MG (40 mg/kg). Values are expressed as means ± S.D. (n = 10). Data were analyzed by single-factor ANOVA with Tukey HSD test. Compared with control group: ^### p < 0.001; Compared with vehicle group: ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001. MG: methyl gallate.